Fluorous Synthesis of 18F Radiotracers with the [18F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process
Fluorous Synthesis of 18F Radiotracers with the [18F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process
复制标题
DOI：
10.1002/anie.200803897
复制
发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Gouverneur, Veronique
中科院分区：
文献类型：
--
作者：
Bejot, Romain;Fowler, Thomas;Gouverneur, Veronique
TAG团队：通过[18F]氟离子对氟磺酸盐进行氟代去标记被发现是制备各种18F标记的假体基团和已知放射性示踪剂的有利策略(见图)。用氟固相萃取(FSPE)从标记物质中分离出过量的氟前体，这表明传统的精馏或繁琐的分离方法是可以避免的。(给出了化学方程式)。©2009 Wiley-VCH Verlag GmbH and Co.KGaA。
Tag team: The flouro-detagging of flourous sulfonates by the [ 18F]fluoride ion was found to be an advantageous strategy for the preparation of various 18F-labeled prosthetic groups and known radiotracers (see picture). Fluorous solid phase extraction (FSPE) was used to separate the excess fluorous precursor from the labeled material, which suggests that traditional purification protocols such as distillation or tedious separation can be avoided. (Chemical Equation Presented). © 2009 Wiley-VCH Verlag GmbH and Co. KGaA.