Hippocampal activation during extinction learning predicts occurrence of the renewal effect in extinction recall
Hippocampal activation during extinction learning predicts occurrence of the renewal effect in extinction recall
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DOI：
10.1016/j.neuroimage.2013.05.025
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发表时间：
2013-11-01
期刊：
影响因子：
5.7
通讯作者：
Tegenthoff, Martin
中科院分区：
文献类型：
--
作者：
Lissek, Silke;Glaubitz, Benjamin;Tegenthoff, Martin
更新效应描述了在灭绝和习得的语境不同的情况下，先前被消灭的反应的重现，从而说明了灭绝学习的语境依赖性。许多关于情境恐惧消退的研究表明，海马体和vmPFC在消退学习和回忆消退的过程中都参与了语境的加工和提取。在这项功能磁共振成像(FMRI)研究中，我们使用了一项预测性学习任务，要求参与者学习线索和特定背景下呈现的结果之间的关系，从而探索了联想学习中更新效应的神经关联。在新环境下的消退过程中，与在与获取环境相同的环境中的消退相比，表现出更新效应(REN)的参与者在包括双侧后海马体和左侧海马旁回在内的脑区表现出更多的激活。在没有表现出更新效应的参与者中，这种激活模式是不存在的(诺伦)。在两组之间的直接比较中，REN组在双侧海马区的激活程度高于NOREN组，而NOREN组在左侧dIPFC(BA 46)和右侧前扣带核(BA 32)的激活程度更高。在消退回忆中，在不同背景下熄灭的刺激再次出现在习得背景中。两组均表现为前额叶激活，REN组主要集中在双侧OFC(BA47)和双侧vmPFC(BA10)，而Noren组表现出更广泛的激活，主要集中在dIPFC的大簇(BA8，9，45)。在直接比较中，Ren组在左侧vmPFC(BA 10)的激活程度高于Noren组，而Noren组在dIPFC(BA 9，46)的激活程度高于Noren组。左侧vmPFC的激活与更新效应反应的数量相关，而dIPFC的激活与更新效应反应呈负相关。这些结果突显了最终产生更新效应或不产生更新效应的过程的不同激活模式，表明在灭绝学习过程中，海马体编码上下文与线索-结果之间的关系，而在灭绝回忆中，vmPFC活跃地提取这种联系。(C)2013 Elsevier Inc.保留所有权利。
The renewal effect describes the reoccurrence of a previously extinguished response in situations where the context of extinction differs from that of acquisition, thus illustrating the context-dependency of extinction learning. A number of studies on contextual fear extinction have implicated hippocampus and vmPFC in processing and retrieval of context both during extinction learning and recall of extinction. In this functional magnetic resonance imaging (fMRI) study we explored the neural correlates of the renewal effect in associative learning, using a predictive learning task that required participants to learn relations between cues and outcomes presented in particular contexts.During extinction in a novel context, compared to extinction in a context identical to the acquisition context, participants who exhibited the renewal effect (REN) showed increased activation in brain regions including bilateral posterior hippocampus and left parahippocampal gyrus. This activation pattern was absent in participants that did not show the renewal effect (NOREN). In direct comparisons between the groups, the REN group exhibited higher activation in bilateral hippocampus, while the NOREN group showed higher activation in left dIPFC (BA 46) and right anterior cingulate (BA 32).During extinction recall, stimuli that had been extinguished in a different context were again presented in the context of acquisition. Here both groups exhibited predominantly prefrontal activation, with the REN group's focus upon bilateral OFC (BA 47) and bilateral vmPFC (BA 10), while the NOREN group showed generally more widespread activation, predominantly in large clusters of dIPFC (BA 8,9,45). In a direct comparison, the REN group showed higher activation than the NOREN group in left vmPFC (BA 10), while NOREN participants exhibited more activation in dIPFC (BA 9,46). Activation in left vmPFC during extinction recall correlated with the number of renewal effect responses, while the dIPFC activation showed a negative correlation with renewal effect responses.These results highlight the differential activation patterns of processes that will eventually produce or not produce a renewal effect, indicating that during extinction learning hippocampus encodes the relation between context and cue-outcome, while in extinction recall vmPFC is active to retrieve this association. (C) 2013 Elsevier Inc. All rights reserved.