Effects of Foeniculi fructus Water Extracts on Activities of Key Enzymes of Lipid Metabolism Related with Obesity
Effects of Foeniculi fructus Water Extracts on Activities of Key Enzymes of Lipid Metabolism Related with Obesity
复制标题
小茴香水提取物对肥胖相关脂质代谢关键酶活性的影响
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Myeon Choe
中科院分区：
文献类型：
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作者：
D. Seo;Tae;Hyun;Myeon Choe
本研究旨在探讨小茴香水提取物对肥胖相关脂代谢关键酶脂蛋白脂酶（LPL）、脂酰辅酶A合成酶（ACS）和激素敏感脂酶（HSL）活性的影响。从正常和肥胖的C57 BL/6 J小鼠的附睾脂肪组织和肝脏中提取LPL和ACS。小茴香水提取物处理显著降低正常和肥胖LPL的活性。当测试100 ppm的小茴香水提取物时，它们使肥胖LPL活性降低12.0%。小茴香水提取物在1，000 ppm浓度下与对照相比活化了7倍的肥胖ACS活性。小茴香水提物处理的细胞HSL mRNA表达较未处理的细胞增加。从各方面考虑，小茴香水提取物有效地抑制脂肪酸流入细胞，并激活代谢过程，使用脂肪酸流动作为能量来源。因此，小茴香水提取物作为一种新型的抗肥胖剂具有很大的潜力。
This study was carried out to estimate beneficial effects of Foeniculi fructus water extract on activities of key enzymes such as lipoprotein lipase (LPL), acyl-CoA synthetase (ACS), and hormone sensitive lipase (HSL) on lipid metabolism related with obesity. LPL and ACS were extracted from the epididymal adipose tissue and liver of C57BL/6J normal and obese mouse. Foeniculi fructus water extract treatment significantly reduced the activity of normal and obese LPL. When 100 ppm of Foeniculi fructus water extracts were tested, they decreased obese LPL activity by 12.0%. Foeniculi fructus water extract activated obese ACS activity by 7-fold compared with control at 1,000 ppm concentration. Expression of HSL mRNA was increased in Foeniculi fructus water extracts treated cells compared with non treated cells. All things considered, Foeniculi fructus water extract efficiently inhibits the influx of fatty acid into the cell, and activates metabolic process that uses fatty acids flowing as an energy source. Thus, it suggest that Foeniculi fructus water extract may have great potential as a novel anti-obesity agent.