Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study
Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study
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DOI：
10.1016/j.schres.2009.01.019
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发表时间：
2009-04-01
影响因子：
4.5
通讯作者：
Takeda, Masatoshi
中科院分区：
文献类型：
--
作者：
Ohi, Kazutaka;Hashimoto, Ryota;Takeda, Masatoshi
G72是与精神分裂症相关的最广泛测试的基因之一。由于G72激活D-氨基酸氧化酶（DAO），G72被称为D-氨基酸氧化酶激活剂（DAOA）。本研究的目的是调查G72和精神分裂症之间的关联在日本人口，使用最大的样本量（1774例精神分裂症患者和2092例健康对照）。我们检测了8个单核苷酸多态性（SNPs），这些多态性在以前的研究中与精神分裂症相关。我们发现了等位基因M22/rs778293、M23/rs3918342和M24/rs 1421292以及M22/rs778293基因型与精神分裂症相关的名义证据，尽管在其他五个SNP中没有等位基因或基因型相关。我们还发现了名义单倍型关联，包括M15/rs 2391191和M19/rs778294与精神分裂症。然而，这些协会不再是积极的校正后，多次测试。我们的结论是，G72可能不会在日本人群中精神分裂症的风险中发挥重要作用。(C)2009爱思唯尔有限公司版权所有。
G72 is one of the most widely tested genes for association with schizophrenia. As G72 activates the D-amino acid oxidase (DAO), G72 is termed D-amino acid oxidase activator (DAOA). The aim of this study is to investigate the association between G72 and schizophrenia in a Japanese population, using the largest sample size to date (1774 patients with schizophrenia and 2092 healthy controls). We examined eight single nucleotide polymorphisms (SNPs), which had been associated with schizophrenia in previous studies. We found nominal evidence for association of alleles, M22/rs778293, M23/rs3918342 and M24/rs1421292, and the genotype of M22/rs778293 with schizophrenia, although there was no association of allele or genotype in the other five SNPs. We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia. However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population. (C) 2009 Elsevier B.V. All rights reserved.