The effect of teriparatide on serum Dickkopf-1 levels in postmenopausal women with established osteoporosis
The effect of teriparatide on serum Dickkopf-1 levels in postmenopausal women with established osteoporosis
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DOI：
10.1111/j.1365-2265.2009.03728.x
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发表时间：
2010-06-01
影响因子：
3.2
通讯作者：
Terpos, Evangelos
中科院分区：
文献类型：
--
作者：
Anastasilakis, Athanasios D.;Polyzos, Stergios A.;Terpos, Evangelos
Objective Parathyroid hormone increases the differentiation of osteoblast precursors through canonical wingless (Wnt) signalling, resulting in an osteoanabolic effect. We aimed to evaluate serum levels of the Wnt-inhibitor Dickkopf-1 (Dkk-1) in postmenopausal women with established osteoporosis and their changes with teriparatide (TPTD-human recombinant PTH 1-34).Design and patients A total of 31 postmenopausal Caucasian women with established osteoporosis (mean age 66.3 +/- 1.4 years) received daily injections of 20 mu g TPTD for 18 months. Follow-up was continued for another 6 months after treatment discontinuation (total duration of treatment 24 months).Measurements Serum samples for total calcium (Ca), intact PTH (iPTH), bone-specific alkaline phosphatase, C-terminal cross-linking telopeptide of type 1 collagen (CTx) and Dkk-1 were obtained at baseline, and at 6, 18 and 24 months after TPTD initiation. Lumbar spine bone mineral density (BMD) was measured before and after 18 months of TPTD treatment. A total of 16 age-and gender-matched healthy controls were also analysed at baseline.Results Serum Dkk-1 levels at baseline were significantly higher in osteoporotic women compared with that in controls (P < 0 002). Dkk-1 increased significantly during TPTD administration (P < 0 044) and decreased to baseline 6 months after TPTD discontinuation. Dkk-1 change was positively correlated to Ca (r = 0.530, P = 0.004) and negatively correlated to iPTH change (r =-0.398, P = 0.040). There was no correlation between Dkk-1 and BMD changes.Conclusions Our data suggest that Dkk-1 levels are increased in women with postmenopausal osteoporosis. TPTD therapy results in further increase of Dkk-1 that may be compensative to TPTD-induced enhanced Wnt signalling.
