THE AMINOACIDURIA OF PREGNANCY
THE AMINOACIDURIA OF PREGNANCY
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妊娠期氨基酸尿
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
G. Cheyne
中科院分区：
文献类型：
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作者：
F. Hytten;G. Cheyne
本文测定了10名健康妇女孕期和产后血浆游离氨基酸浓度及其尿液中游离氨基酸排泄量。几乎所有氨基酸在怀孕期间的排泄量都比未怀孕时更大，似乎有三种可定义的模式。甘氨酸、组氨酸、苏氨酸、丝氨酸和丙氨酸5种氨基酸的排泄量在妊娠早期迅速增加，是未妊娠的3~4倍，并随着妊娠的进行继续增加。另外7种氨基酸：赖氨酸、胱氨酸、牛磺酸、酪氨酸、苯丙氨酸、缬氨酸和亮氨酸，在妊娠早期排泄量也显著增加，但之后排泄量有下降的趋势。其余六种氨基酸的排泄量几乎没有增加。
The concentration of free amino acids in plasma and their excretion in urine was measured serially in ten healthy women during pregnancy and again postpartum. Almost all amino acids were excreted in greater amounts during pregnancy than in the non‐pregnant state and there appeared to be three definable patterns. The excretion of the five amino acids lost in greatest amount, glycine, histidine, threonine, serine and alanine, increased rapidly in early pregnancy to three or four times the non‐pregnant rate and continued to increase as pregnancy proceeded. For seven others: lysine, cystine, taurine, tyrosine, phenylalanine, valine and leucine, there was also a greatly increased excretion in early pregnancy, but there after excretion tended to fall. The remaining six amino acids measured showed little or no increase in excretion.