Thymoma: an immunohistochemical study.
Thymoma: an immunohistochemical study.
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胸腺瘤：一项免疫组织化学研究。
DOI：
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发表时间：
1984
影响因子：
3.5
通讯作者：
R. Brynes
中科院分区：
文献类型：
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作者：
Wing Cheong Chan;G. Zaatari;S. Tabei;M. Bibb;R. Brynes
使用一组单克隆抗体对四个胸腺瘤（其中两个来自重症肌无力患者）进行了研究。几乎所有相关淋巴细胞都是具有常见胸腺淋巴细胞表型的T细胞，这表明肿瘤上皮可以提供保留或可能吸引未成熟T细胞的微环境。 HLA-Dr 抗原由血管周围空间中的一些上皮细胞和许多淋巴细胞表达。 Leu-7 抗原存在于上皮细胞亚群上，并且在不同的胸腺瘤中具有高度可变的表达。重症肌无力患者中携带 OKT8 定义抗原的淋巴细胞百分比似乎较低，而其他标记物的表达似乎没有一致或显着差异。不同形态的胸腺瘤的淋巴细胞亚群似乎没有显着差异，并且没有证据表明胸腺瘤分化为皮质区和髓质区。
Four thymomas, two from patients with myasthenia gravis, were studied using a panel of monoclonal antibodies. Almost all the associated lymphocytes were T-cells with the common thymic lymphocyte phenotype, suggesting that the neoplastic epithelium can provide a microenvironment that retains or perhaps attracts immature T-cells. HLA-Dr antigens were expressed by some of the epithelial cells and many of the lymphoid cells in the perivascular space. The Leu-7 antigen was present on a subset of epithelial cells and had a highly variable expression in different thymomas. The percentage of lymphocytes bearing the OKT8-defined antigen appeared to be lower in patients with myasthenia gravis, while the expression of other markers did not appear to be consistently or significantly different. There did not appear to be marked differences in the lymphocyte subpopulations of thymomas with different morphology, and there was no evidence of differentiation of the thymomas into cortical and medullary areas.