QMSim: a large-scale genome simulator for livestock
QMSim: a large-scale genome simulator for livestock
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DOI：
10.1093/bioinformatics/btp045
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发表时间：
2009-03-01
期刊：
影响因子：
5.8
通讯作者：
Schenkel, Flavio S.
中科院分区：
文献类型：
--
作者：
Sargolzaei, Mehdi;Schenkel, Flavio S.
QMSim被设计用于模拟多个和复杂的家畜谱系中的大规模基因分型数据。模拟基本上分两步进行。在第一步中，模拟历史种群以建立突变-漂移平衡，在第二步中，生成最近的种群结构，这可能是非常复杂的。可以模拟各种各样的基因组结构，从无穷小模型到单位点模型。该程序在计算时间和内存要求方面是有效的。
QMSim was designed to simulate large-scale genotyping data in multiple and complex livestock pedigrees. The simulation is basically carried out in two steps. In the first step, a historical population is simulated to establish mutation-drift equilibrium, and in the second step, recent population structures are generated, which can be very complex. A wide variety of genome architectures, ranging from infinitesimal model to single-locus model, can be simulated. The program is efficient in terms of computing time and memory requirements.