INTERACTIONS IN METAL CARCINOGENICITY
INTERACTIONS IN METAL CARCINOGENICITY
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DOI：
10.1016/0378-4274(94)90045-0
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发表时间：
1994-06-01
影响因子：
3.5
通讯作者：
BEYERSMANN, D
中科院分区：
文献类型：
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作者：
BEYERSMANN, D
镉、铬、钴和镍的致癌性和遗传毒性在很大程度上取决于它们的化学配体（形态），这些配体调节它们的生物利用度和与生化靶点的反应性。除六价铬外，致癌金属化合物只有微弱的遗传毒性。然而，致癌金属镉、钴和镍的离子，以及非致癌的铅，抑制由直接遗传毒性剂如紫外线照射和烷基化物质损伤的DNA的修复，从而增强后者的作用。这些影响被解释为有毒金属离子与镁，钙和锌离子的生物化学功能的干扰。
The carcinogenicity and genotoxicity of cadmium, chromium, cobalt and nickel strongly depend on their chemical ligands (speciation) which modulate their bioavailability and reactivity with biochemical targets. With the exception of hexavalent chromium, carcinogenic metal compounds are only weakly genotoxic. However, the ions of the carcinogenic metals cadmium, cobalt and nickel, and also the noncarcinogenic lead, inhibit the repair of DNA damaged by direct genotoxic agents like UV irradiation and alkylating substances, thereby enhancing the effects of the latter agents. These effects are interpreted by the interference of the toxic metal ions with biochemical functions of magnesium, calcium and zinc ions.