STAT3 - A STAT FAMILY MEMBER ACTIVATED BY TYROSINE PHOSPHORYLATION IN RESPONSE TO EPIDERMAL GROWTH-FACTOR AND INTERLEUKIN-6
STAT3 - A STAT FAMILY MEMBER ACTIVATED BY TYROSINE PHOSPHORYLATION IN RESPONSE TO EPIDERMAL GROWTH-FACTOR AND INTERLEUKIN-6
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DOI：
10.1126/science.8140422
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发表时间：
1994-04-01
期刊：
影响因子：
56.9
通讯作者：
DARNELL, JE
中科院分区：
文献类型：
--
作者：
ZHONG, Z;WEN, ZL;DARNELL, JE
STAT蛋白家族具有双重功能：信号转导和转录激活。一个新的家族成员，Stat 3，通过酪氨酸磷酸化激活作为DNA结合蛋白，响应于表皮生长因子（EGF）和白细胞介素-6（IL-6），而不是干扰素γ（IFN-γ）。 这种磷蛋白很可能与STAT家族的第一个成员Stat 91（重命名为Stat 1alpha）形成同源二聚体和异源二聚体，Stat 91由IFN和EGF激活。不同STAT蛋白对不同配体反应的差异活化应有助于解释细胞表面核信号传导的特异性。
The STAT family of proteins carries out a dual function: signal transduction and activation of transcription. A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). It is likely that this phosphoprotein forms homodimers as well as heterodimers with the first described member of the STAT family, Stat91 (renamed Stat1alpha), which is activated by the IFNs and EGF. Differential activation of different STAT proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface.