Utah family-based analysis: Past, present and future
Utah family-based analysis: Past, present and future
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DOI：
10.1159/000112368
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发表时间：
2008-01-01
期刊：
影响因子：
1.8
通讯作者：
Albright, Lisa A. Cannon
中科院分区：
文献类型：
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作者：
Albright, Lisa A. Cannon
30多年前，犹他州创建了一个与表型数据相关的独特家谱资源。在这里，我们回顾一下这个资源的历史和内容。此外，我们回顾了目前使用的三种方法，结合这个资源来定义表型的遗传贡献，并确定易感基因负责这些表型。示例分析和高风险家系。最后，我们简要回顾一下这种资源或其他类似资源在未来可能会扩展的方式。
A unique genealogical resource linked to phenotype data was created in Utah over 30 years ago. Here we review the history and content of this resource. In addition, we review three current methodologies used in conjunction with this resource to define the heritable contribution to phenotypes and to identify predisposition genes responsible for these phenotypes. Example analyses and high-risk pedigrees are presented. Finally we briefly review ways this resource, or others like it, may expand in future.