Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry
Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry
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半胱胺诱导的中枢生长抑素样免疫活性的耗竭：对行为、学习、记忆和脑神经化学的影响
DOI：
10.1016/0006-8993(87)90060-6
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发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
Kenneth L. Davis
中科院分区：
文献类型：
--
作者：
V. Haroutunian;R. Mantin;G. Campbell;G. Tsuboyama;Kenneth L. Davis
研究了广泛剂量的全身施用的半胱胺对运动行为、被动回避记忆、皮质和脑脊液生长抑素样免疫活性以及多巴胺和去甲肾上腺素的皮质水平的影响。高剂量的半胱胺（200和250 mg/kg s.c.）导致了持续的运动激活150 mg/kg及以上剂量导致头颈震颤和排便增加。当在获得被动回避反应后立即施用半胱胺时，50 mg/kg及以上的剂量导致被动回避保持测试表现的显著减弱。50 mg/kg及以上剂量的半胱胺使皮质生长抑素样免疫活性降低约50%。皮质生长抑素样免疫活性的耗竭伴随着脑脊液中生长抑素样免疫活性的快速上升。除了耗尽生长抑素样免疫活性外，高剂量半胱胺（150 mg/kg及以上）还引起去甲肾上腺素和多巴胺皮质水平的变化，使人联想到多巴胺-β-羟化酶抑制。这一系列的实验结果表明，生长抑素，除了其对激素调节的影响，可能在行为和被动回避学习和记忆中发挥重要作用。半胱胺引起的遗忘症可能是由于生长抑素从组织库释放到CSF中，而不是生长抑素本身耗尽。高剂量半胱胺的儿茶酚胺能效应也可能促成所观察到的行为缺陷。
The effects of a wide range of doses of systemically administered cysteamine were studied on locomotor behavior, passive avoidance memory, cortical and cerebrospinal fluid somatostatin-like immunoactivity and cortical levels of dopamine and norepinephrine. High doses of cysteamine (200 and 250 mg/kg s.c.) led to sustained locomotor activation. Doses of 150 mg/kg and above resulted in head and neck tremor and increased defecation. When cysteamine was administered immediately following the acquisition of a passive avoidance response, doses of 50 mg/kg and above resulted in significant attenuation of passive avoidance retention test performance. Cysteamine in doses of 50 mg/kg and above depleted cortical somatostatin-like immunoactivity by approximately 50%. The depletion of cortical somatostatin-like immunoactivity was accompanied by a rapid rise in somatostatin-like immunoactivity in cerebrospinal fluid. In addition to the depletion of somatostatin-like immunoactivity, high doses of cysteamine (150 mg/kg and above) produced changes in cortical levels of norepinephrine and dopamine, reminiscent of dopamine-β-hydroxylase inhibition. The results of this series of experiments suggest that somatostatin, in addition to its effects on hormonal regulation, may play an important role in behavior and passive avoidance learning and memory. It is possible that the amnesia produced by cysteamine may have been due to the release of somatostatin into CSF from tissue stores, rather than somatostatin depletion per se. It is also possible that the catecholaminergic effects of high doses of cysteamine contribute to the behavioral deficts observed.
半胱胺对大鼠促甲状腺素和免疫反应性β-内啡肽分泌的影响。
影响因子：
4.8
作者：
Millard,WJ;Sagar,SM;Badger,TM;Carr,DB;Arnold,MA;Spindel,E;Kasting,NW;Martin,JB
通讯作者：
Martin,JB
半胱胺对雄性大鼠生长激素分泌的影响。
影响因子：
4.8
作者：
Millard,WJ;Sagar,SM;Badger,TM;Martin,JB
通讯作者：
Martin,JB
给予半胱胺可耗尽大鼠组织中的生长抑素。
影响因子：
4.8
作者：
Szabo,S;Reichlin,S
通讯作者：
Reichlin,S