Emphysema quantification in inflation-fixed lungs using low-dose computed tomography and 3He magnetic resonance imaging.
Emphysema quantification in inflation-fixed lungs using low-dose computed tomography and 3He magnetic resonance imaging.
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DOI：
10.1097/rct.0b013e3181e480f9
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发表时间：
2010-09
影响因子：
1.3
通讯作者：
Conradi MS
中科院分区：
文献类型：
--
作者：
Gierada DS;Woods JC;Jacob RE;Bierhals AJ;Choong CK;Bartel ST;Chang YV;Das NA;Hong C;Lutey BA;Ritter JH;Pilgram TK;Cooper JD;Patterson GA;Battafarano RJ;Meyers BF;Yablonskiy DA;Conradi MS
评价使用膨胀固定肺组织进行肺气肿定量CT和3 He MR扩散成像。研究了14例接受完全或肺叶切除术的慢性阻塞性肺疾病严重程度不同的受试者。CT测量的肺衰减和MR测量的超极化3 He表观扩散系数（ADC）的切除标本固定在膨胀与加热福尔马林蒸汽固定前获得的测量进行了比较。固定前平均CT肺气肿指数为56% ± 17%，固定后为58% ± 19%（P=0.77; R=0.76）。指数差异与肺容量差异相关（R2=0.47）。固定前平均3 He ADC为0.40 ± 0.15 cm 2/sec，固定后为0.39 ± 0.14 cm 2/sec（P=0.03，R=0.98）。CT肺气肿指数与3 He ADC值在固定前（R=0.89）和固定后（R=0.79）均呈正相关。未固定和充气固定肺部的CT和3 He MR成像测量结果的一致性支持使用充气固定肺部进行肺气肿的定量成像研究。
To evaluate the use of inflation-fixed lung tissue for emphysema quantification with CT and 3He MR diffusion imaging. Fourteen subjects representing a range of chronic obstructive pulmonary disease severity who underwent complete or lobar lung resection were studied. CT measurements of lung attenuation and MR measurements of the hyperpolarized 3He apparent diffusion coefficient (ADC) in resected specimens fixed in inflation with heated formalin vapor were compared with measurements obtained before fixation. The mean CT emphysema index was 56% ± 17% before and 58% ± 19% after fixation (P=0.77; R=0.76). Index differences correlated with differences in lung volume (R2=0.47). The mean 3He ADC was 0.40 ± 0.15 cm2/sec before and 0.39 ± 0.14 cm2/sec after fixation (P=0.03, R=0.98). The CT emphysema index and the 3He ADC were correlated before (R=0.89) and after fixation (R=0.79). Concordance of CT and 3He MR imaging measurements in unfixed and inflation-fixed lungs supports the use of inflation-fixed lungs for quantitative imaging studies in emphysema.