Rewarding properties of social interactions in adolescent and adult male and female rats: Impact of social versus isolate housing of subjects and partners
Rewarding properties of social interactions in adolescent and adult male and female rats: Impact of social versus isolate housing of subjects and partners
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DOI：
10.1002/dev.20025
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发表时间：
2004-11-01
影响因子：
2.2
通讯作者：
Spear, LP
中科院分区：
文献类型：
--
作者：
Douglas, LA;Varlinskaya, EI;Spear, LP
社会互动已被证明是有益的青少年和成年大鼠，但是，一直很少强调比较的强度奖励价值的社会刺激个体发育。由于社会互动的年龄差异可能会因性别或住房情况而异，本研究评估了青少年和成年雄性和雌性Sprague-Dawley大鼠的社会条件性位置偏好（CPP），这些大鼠以社会或隔离方式饲养，并以分组饲养或隔离饲养的伴侣为条件。隔离动物的性别和年龄表现出社会CPP，最强的preference出现在青春期的男性。社会CPP是不明显的，而组居住的成年人发展的偏好，以前与类似的合作伙伴配对的隔间，但是，当社会居住的青少年条件与孤立的合作伙伴，社会CPP没有出现。社会CPP的年龄差异可能反映了与社会行为调节有关的脑系统中与年龄相关的神经改变。(C)2004 Wiley Periodicals，Inc.
Social interactions have been shown to be rewarding for adolescent and adult rats; however, there has been little emphasis on comparing the strength of the rewarding value of social stimuli across ontogeny. Since age differences in social interactions may vary with sex or housing circumstances, the present study assessed social conditioned place preference (CPP) in adolescent and adult male and female Sprague-Dawley rats housed either socially or in isolation and conditioned with either group-housed or isolate-housed partners. Isolated animals of both sexes and ages demonstrated social CPP, with the strongest prefrence emerging in adolescent males. Social CPP was not evident in group-housed adults whereas group-housed adolescents developed a preference for the compartment previously paired with similarly housed partners; however when socially housed adolescents were conditioned with isolated partners, social CPP did not emerge. Age differences in social CPP may reflect age-related neural alterations in brain systems implicated in regulation of social behavior. (C) 2004 Wiley Periodicals, Inc.