Oxidative stress in neurodegeneration.
Oxidative stress in neurodegeneration.
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DOI：
10.1155/2011/572634
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发表时间：
2011
影响因子：
--
通讯作者：
Pant HC
中科院分区：
文献类型：
--
作者：
Shukla V;Mishra SK;Pant HC
研究表明，氧化应激在神经退行性疾病中起着普遍的作用。活性氧(ROS)引起的氧化应激的主要来源与线粒体作为内源性来源有关。虽然从神经退行性疾病患者的组织中有大量的证据表明线粒体的形态、生化和分子异常，但氧化应激本身是导致神经退行性变的原因，还是作为继发性表现的神经退行性变过程的一部分，目前还不是很清楚。本文首先概述了氧化应激是如何发生的，讨论了各种氧化剂和抗氧化剂，以及氧化应激在疾病中的作用。它强调了氧化应激在阿尔茨海默氏症、帕金森氏症、亨廷顿氏病和肌萎缩侧索硬化症等神经退行性疾病中的作用。论文的最后部分描述了氧化应激导致细胞周期蛋白依赖性激酶5(CDK5)过度活动与神经退行性变相关的解除调控的作用。
It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative diseases. Major source of oxidative stress due to reactive oxygen species (ROS) is related to mitochondria as an endogenous source. Although there is ample evidence from tissues of patients with neurodegenerative disorders of morphological, biochemical, and molecular abnormalities in mitochondria, it is still not very clear whether the oxidative stress itself contributes to the onset of neurodegeneration or it is part of the neurodegenerative process as secondary manifestation. This paper begins with an overview of how oxidative stress occurs, discussing various oxidants and antioxidants, and role of oxidative stress in diseases in general. It highlights the role of oxidative stress in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's diseases and amyotrophic lateral sclerosis. The last part of the paper describes the role of oxidative stress causing deregulation of cyclin-dependent kinase 5 (Cdk5) hyperactivity associated with neurodegeneration.