Antiviral cytotoxic T lymphocyte induction and vaccination.
Antiviral cytotoxic T lymphocyte induction and vaccination.
复制标题
抗病毒细胞毒性 T 淋巴细胞诱导和疫苗接种。
DOI：
10.1093/clinids/10.1.16
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Martin,S
中科院分区：
文献类型：
--
作者：
Rouse,BT;Norley,S;Martin,S
在开发抵抗病毒感染的疫苗时，重要的是生产产生最适合提供保护和避免免疫病理学的免疫应答类型的试剂。从感染中恢复是T细胞免疫的主要作用，而识别病毒感染细胞（细胞毒性T淋巴细胞）并杀死它们（通常在新病毒复制之前）的细胞是恢复过程的关键组成部分。细胞毒性T淋巴细胞在感染负荷高的情况下特别重要。在这篇综述中，细胞和介质，以及病毒和宿主细胞抗原参与抗病毒诱导的细胞毒性T淋巴细胞，进行了讨论。特别注意的是细胞内的处理途径所采取的病毒抗原和结果方面的识别细胞毒性T淋巴细胞的重要性。新类型的疫苗-特别是亚单位，抗独特型，和重组病毒载体-在其可能的有效性诱导细胞毒性T淋巴细胞方面进行了讨论。
In developing vaccines to counteract viral infections, it is important to produce reagents that engender the type of immune response best suited to provide protection and avoid immunopathology. Recovery from infection is the principal role of T cell immunity, and cells that recognize virus-infected cells (cytotoxic T lymphocytes) and kill them-often before new virus is replicated — represent a crucial component of the recovery process. The cytotoxic T lymphocytes are particularly important in situations where the load of infection is high. In this review the cells and mediators, as well as the viral and host cell antigens involved in antiviral induction of cytotoxic T lymphocytes, are discussed. Particular attention is paid to the importance of the intracellular pathway of processing taken by viral antigens and the outcome in terms of the recognition of cytotoxic T lymphocytes. The new types of vaccines — especially subunits, antiidiotypes, and recombinant viral vectors — are discussed in terms of their likely effectiveness at inducing cytotoxic T lymphocytes.