Identifying cutoff scores for the EORTC QLQ-C30 and the head and neck cancer-specific module EORTC QLQ-H&N35 representing unmet supportive care needs in patients with head and neck cancer
Identifying cutoff scores for the EORTC QLQ-C30 and the head and neck cancer-specific module EORTC QLQ-H&N35 representing unmet supportive care needs in patients with head and neck cancer
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DOI：
10.1002/hed.24266
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发表时间：
2016-04-01
影响因子：
2.9
通讯作者：
Verdonck-de Leeuw, Irma M.
中科院分区：
文献类型：
--
作者：
Jansen, Femke;Snyder, Claire F.;Verdonck-de Leeuw, Irma M.
背景资料。这项研究调查了欧洲癌症研究和治疗组织生活质量问卷核心30个问题(EORTC QLQ-C30)和头颈癌特定模块(QLQ-H&N35)的截止分数，以确定可能需要临床关注的头颈癌患者。96名头颈部癌症患者完成了EORTC QLQ-C30/H&N35和关于支持性护理需求的问题。对于所有有能力区分有无需求的患者的EORTC领域(受试者工作特征曲线下的面积[AUC]>；=0.70)，计算潜在截断值的准确性(例如，敏感性和特异性)。在28个连续的EORTC QLQ-C30/H&N35领域中，有7个领域有90个(功能领域)和5~10个(症状领域)的临界值(敏感度和特异度分别为0.80和0.60)。在其他5个领域发现了临界值(敏感度和特异度=0.70和特异度=0.60或敏感度和特异度=0.80和特异度=0.50)。这项研究根据患者对支持性护理需求的看法，提供了EORTC QLQ-C30和H&N35的分界值。未来还需要对这些截止分数的可重复性进行研究。(C)2015年威利期刊公司。
Background. This study investigates cutoff scores for the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30-questions (EORTC QLQ-C30) and head and neck cancer-specific module (QLQ-H&N35) to identify patients with head and neck cancer who may require clinical attention.Methods. Ninety-six patients with head and neck cancer completed the EORTC QLQ-C30/H&N35 and questions on supportive care needs. For all EORTC domains with the ability to discriminate between patients with and without unmet needs (area under the receiver operating characteristic curve [AUC] >= 0.70), the accuracy (eg, sensitivity and specificity) of potential cutoff scores were calculated.Results. Cutoff scores (sensitivity >= 0.80 and specificity >= 0.60) of 90 (functioning domains) and 5 to 10 (symptom domains) were found on 7 of 28 continuous EORTC QLQ-C30/H&N35 domains. Borderline cutoff scores (sensitivity >= 0.70 and specificity >= 0.60 or sensitivity >= 0.80 and specificity >= 0.50) were found on 5 other domains.Conclusions. This study provided cutoff scores on the EORTC QLQ-C30 and H&N35 based on patients' perceptions of their needs for supportive care. Future research is needed on the replicability of these cutoff scores. (C) 2015 Wiley Periodicals, Inc.