Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application
Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application
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DOI：
10.1016/j.steroids.2005.01.007
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发表时间：
2005-07-01
期刊：
影响因子：
2.7
通讯作者：
Fiore, C
中科院分区：
文献类型：
--
作者：
Armanini, D;Nacamulli, D;Fiore, C
皮质醇参与脂肪的分布和沉积，其作用受I I P-羟基类固醇脱氢酶的活性调节。甘草根的活性成分甘草次酸可阻断 I I P-羟基类固醇脱氢酶 1 型，从而减少脂肪细胞水平上皮质醇的可用性。我们评估了局部涂抹含有甘草次酸的乳膏在大腿脂肪厚度中的效果，18 名正常健康女性（年龄范围 20-33 岁） BMI 被随机分配至主要大腿水平的治疗组，分别使用含 2.5% 甘草次酸的乳膏（n = 9）或仅含赋形剂的安慰剂乳膏（n = 9）。在治疗 I 个月之前和之后，测量了大腿浅层脂肪层的周长和厚度（通过超声分析）。浅层脂肪层的周长和厚度均显着减少 与未治疗的对照组大腿和使用安慰剂乳膏治疗的对照受试者相比。没有观察到血压变化。血浆肾素活性、血浆醛固酮或皮质醇、甘草次酸对皮下脂肪厚度的影响可能与脂肪细胞水平的I型P-羟基类固醇脱氢酶I型阻断有关；因此，甘草次酸可以有效地用于减少不必要的局部脂肪堆积。 (c) 2005 Elsevier Inc. 保留所有权利。
Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of I I P-hydroxysteroid dehydrogenase. Glycyrrhetinic acid, the active principle of licorice root, blocks I I P-hydroxy steroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes.We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh,Eighteen healthy women (age range 20-33 years) with normal BMI were randomly allocated to treatment, at the level of the dominant thigh, with a cream containing 2.5% glycyrrhetinic acid (n = 9) or with a placebo cream containing the excipients alone (n = 9) Before and after I month of treatment both the circumference and the thickness of the superficial fat layer of the thighs (by ultrasound analysis) were measured.The circumference and the thickness of the superficial fat layer were significantly reduced in comparison to the controlateral untreated thigh and to control subjects treated with the placebo cream.No changes were observed in blood pressure. plasma renin activity, plasma aldosterone or cortisol,The effect of glycyrrhetinic acid on the thickness of subcutaneous fat was likely related to a block of I I P-hydroxysteroid dehydrogenase type I at the level of fat cells;, therefore, glycyrrhetinic acid could be effectively used in the reduction of unwanted local fat accumulation. (c) 2005 Elsevier Inc. All rights reserved.