Pregnancy-induced hyporesponsiveness to paternal alloantigens. I. Alterations of humoral immunity in primiparous female rats.
Pregnancy-induced hyporesponsiveness to paternal alloantigens. I. Alterations of humoral immunity in primiparous female rats.
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妊娠引起的对父亲同种异体抗原的低反应。
DOI：
10.1097/00007890-198211000-00003
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发表时间：
1982
期刊：
影响因子：
6.2
通讯作者：
Head,JR
中科院分区：
文献类型：
--
作者：
Head,JR
使用RT1不相容的大鼠研究单次同种异体妊娠对雌性对父本同种异体抗原的反应性的影响。 Fischer (FI) 品系雌性在第一窝幼崽出生后的不同时间被 DA 雄性移植，皮肤来自 DA 供体或其自己的 F 1 杂交后代。对照由类似地嫁接的处女FI雌性和已生育同基因（即FI）窝的FI雌性提供。尽管同种异体初产雌性与对照一样迅速排斥同种异体皮肤移植物，但与处女和妊娠对照相比，它们响应这些移植物产生血凝同种抗体的能力严重下降。同种异体怀孕雌性的“主要”反应中从 IgM 到 IgG 产生的转变也受到影响，并且发生延迟。检测到的这些较低水平的抗体反映了真正的反应能力下降，而不是测试系统揭示母体血清中凝集抗体的能力的缺陷。在同种异体妊娠第 9 至 12 天移植的雌性中，抗体反应明显下降，但在此之前则不然。这种低反应性是父系抗原特有的，因为只有当父系菌株和移植物供体共享显着的同种抗体诱导 RT1 抗原时，才会在第三方测试中观察到这种低反应性。
The effect of a single allogeneic pregnancy on females' responsiveness to paternal alloantigens was investigated using RTl-incompatible rats. Fischer (FI) strain females were grafted at various times after the birth of their first litters by DA males with skin from either DA donors or their own F 1 hybrid offspring. Controls were provided by similarly grafting virgin FI females and FI females who had borne syngeneic, ie, FI, litters. Although allogeneically primiparous females rejected the skin allografts as promptly as controls, their capacity to produce hemagglutinating alloantibodies in response to these grafts was severely depressed compared with that of both virgin and pregnancy controls. The switch from IgM to IgG production in the “primary” response of the allogeneically pregnant females was also affected, being of delayed onset. These lower levels of antibodies detected reflected a true diminished capacity to respond and not a shortcoming in the ability of the test system to reveal agglutinating antibodies in maternal serum. Decreased antibody responses were demonstrable in females grafted at 9 to 12 days of allogeneic gestation, but not before. This hyporesponsiveness was specific for paternal antigens in that it was observed in third-party tests only if the paternal strain and graft donor shared significant alloantibody-inducing RT1 antigens.