Vascular endothelial growth factor and tissue factor in patients with established peripheral artery disease: a link between angiogenesis and thrombogenesis?
Vascular endothelial growth factor and tissue factor in patients with established peripheral artery disease: a link between angiogenesis and thrombogenesis?
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DOI：
10.1042/cs20020182
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发表时间：
2003-04-01
期刊：
影响因子：
6
通讯作者：
Lip, GYH
中科院分区：
文献类型：
--
作者：
Makin, AJ;Chung, NAY;Lip, GYH
越来越多的证据指向动脉粥样硬化及其表现中的促血栓形成状态，例如外周动脉疾病（PAD），其与血栓形成相关的并发症相关，例如急性肢体缺血、移植物血栓形成和中风。我们推测PAD血栓形成风险的增加可能与血管生成异常有关，因此，未来血管疾病的风险增加。为了验证这一假设，我们测量了组织因子（TF）的血浆水平和血管生成指标的相关水平，即血管内皮生长因子（VEGF）及其可溶性受体sFlt-1。我们研究了234例经证实患有PAD（踝臂压力指数< 0.8）的患者（145例男性;平均年龄68.6 ± 10岁），并将他们与50名健康对照者进行了比较。VEGF（P = 0.001）和TF（P = 0.043）水平在患者中较对照组升高。两组患者VEGF和TF水平均呈显著相关（斯皮尔曼r = 0.351，P < 0.001），健康对照组VEGF和TF水平呈显著相关（斯皮尔曼r = 0.335，P = 0.017）。在PAD患者中，VEGF水平与性别有关，女性的水平高于男性。sFlt-1水平在患者和对照组之间或患者亚组之间没有差异。sFlt-1与TF（斯皮尔曼r = 0.268，P < 0.001）和VEGF（斯皮尔曼r = 0.499，P < 0.001）之间存在显著相关性。总之，与对照组相比，患有经证实的PAD的患者具有更高的TF和VEGF血浆水平，两者之间具有显著相关性。这表明PAD的高凝状态与血管生成过程之间存在联系。
Increasing evidence points towards a prothrombotic state in atherosclerosis and its manifestations, such as peripheral artery disease (PAD), which is associated with thrombosis-related complications, such as acute limb ischaemia, graft thrombosis and stroke. We hypothesized that the increased risk of thrombogenesis in PAD may be related to abnormal angiogenesis and, thus, an increased risk of future vascular disease. To test this hypothesis, we measured plasma levels of tissue factor (TF) and related levels to indices of angiogenesis, that is vascular endothelial growth factor (VEGF) and its soluble receptor sFlt-1. We studied 234 patients (145 males; mean age 68.6+/-10 years) with proven PAD (ankle brachial pressure index < 0.8) and compared them with 50 healthy controls. Levels of VEGF (P = 0.001) and TF (P = 0.043) were increased in patients compared with controls. There were significant correlations between VEGF and TF levels in both patients (Spearman r = 0.351, P < 0.001) and healthy controls (Spearman r = 0.335, P = 0.017). Amongst PAD patients, levels of VEGF were related to gender, with women having higher levels than men. There was no difference in the levels of sFlt-1 between the patients and controls, or between the subgroups of patients. There were however significant correlations between the levels of sFlt-1 and TF (Spearman r = 0.268, P < 0.001) and between sFlt-1 and VEGF (Spearman r = 0.499, P < 0.001). In conclusion, patients suffering from proven PAD have higher plasma levels of TF and VEGF compared with controls, with a significant correlation between the two. This suggests a link between the hypercoagulable state in PAD and the process of angiogenesis.