The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study (InterGEN): Design and Methods for Recruitment and Psychological Measures.
The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study (InterGEN): Design and Methods for Recruitment and Psychological Measures.
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DOI：
10.1097/nnr.0000000000000163
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发表时间：
2016-07
期刊：
影响因子：
2.5
通讯作者：
Taylor JY
中科院分区：
文献类型：
--
作者：
Crusto CA;Barcelona de Mendoza V;Connell CM;Sun YV;Taylor JY
虽然研究表明基因组学和环境压力因素会影响血压，但很少有研究研究它们的综合影响，特别是在非洲裔美国人中。我们介绍了遗传和心理因素对血压的代际影响（InterGEN）研究的招募方法和心理措施，该研究旨在调查遗传（G）和环境（E）（心理）压力对非裔美国人母子二人血压的个体和综合影响。遗传学方法在其他地方介绍，但在这里，我们提出的招聘方法，心理措施，和分析计划，这些环境压力。这项纵向研究将入组250对母子（N = 500）。研究参与仅限于以下女性：（a）年龄≥ 21岁;（B）自我认同为非裔美国人或黑人;（c）会说英语;（d）未患有确定的精神疾病或认知障碍;（e）有3 - 5岁的亲生子女。评估的主要环境压力源是养育压力，感知的种族主义和歧视，以及产妇的心理健康。协变量包括年龄、吸烟（母亲）和性别（儿童）。研究结果变量为收缩压和舒张压。主要分析结果是遗传-环境相互作用分析（G × E），但首先将单独评估主效应（G）和（E）。遗传分析（G）和互作分析（G × E）将在配套文件中介绍，并将包括实验室程序。将使用描述性统计和广义估计方程（GEE）模型对环境压力源对血压的影响进行统计建模。这里提出的方法包括研究的基本原理，社区参与和招募协议，心理变量测量，并评估环境压力源和血压的关联分析计划。本研究可为其他研究和干预措施的制定提供基础，以降低高血压的风险，并为这一高危人群提出有针对性的健康促进计划。
Although studies show that genomics and environmental stressors affect blood pressure, few studies have examined their combined effects, especially in African Americans. We present the recruitment methods and psychological measures of the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) study, which seeks to investigate the individual and combined effects of genetic (G) and environmental (E) (psychological) stressors on blood pressure in African American, mother-child dyads. Genetic methods are presented elsewhere, but here we present the recruitment methods, psychological measures, and analysis plan for these environmental stressors. This longitudinal study will enroll 250 mother-child dyads (N = 500). Study participation is restricted to women who: (a) are ≥ 21 years of age; (b) self-identify as African American or Black; (c) speak English; (d) do not have an identified mental illness or cognitive impairment; and (e) have a biological child between three to five years old. The primary environmental stressors assessed are parenting stress, perceived racism and discrimination, and maternal mental health. Covariates include age, cigarette smoking (for mothers), and gender (for children). The study outcome variables are systolic and diastolic blood pressure. The main analytic outcome is genetic-by-environment interaction analyses (G × E), however, main effects (G) and (E) will be individually assessed first. Genetic (G) and interaction analyses (G × E) are described in a companion paper and will include laboratory procedures. Statistical modeling of environmental stressors on blood pressure will be done using descriptive statistics and generalized estimating equation (GEE) models. The methodology presented here includes the study rationale, community engagement and recruitment protocol, psychological variable measurement, and analysis plan for assessing the association of environmental stressors and blood pressure. This study may provide the foundation for other studies and development of interventions to reduce the risk for hypertension, and to propose targeted health promotion programs for this high-risk population.