Heme oxygenase-1 as a protective gene.
Heme oxygenase-1 as a protective gene.
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DOI：
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发表时间：
2002
影响因子：
2.6
通讯作者：
F. Bach
中科院分区：
文献类型：
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作者：
F. Bach
血红素加氧酶催化血红素降解的限速步骤，导致一氧化碳、铁和胆绿素的形成，后者随后被胆绿素还原酶还原为胆红素。这种酶促反应的产物具有重要的生物效应，包括抗氧化、抗炎和细胞保护功能。血红素加氧酶(HO)的三种亚型已被描述：两种组成表达的亚型，HO-2和HO-3，以及一种可诱导的亚型，HO-1，它是对几种伤害刺激的适应性反应，包括血红素、高氧、低氧、内毒素和重金属。HO-1的诱导与多种临床相关疾病有关，包括移植排斥反应、高血压、动脉粥样硬化、肺损伤、内毒素休克等。现就HO-1的保护功能作一综述。
Heme oxygenases catalyze the rate-limiting step in heme degradation, resulting in the formation of carbon monoxide, iron and biliverdin that is subsequently reduced to bilirubin by biliverdin reductase. The products of this enzymatic reaction have important biological effects, including antioxidant, anti-inflammatory and cytoprotective functions. Three isoforms of heme oxygenase (HO) have been described: two constitutively expressed isoforms, HO-2 and HO-3, and an inducible isoform, HO-1 that is increased as an adaptive response to several injurious stimuli including heme, hyperoxia, hypoxia, endotoxin and heavy metals. Induction of HO-1 has been implicated in numerous clinically relevant disease states including transplant rejection, hypertension, atherosclerosis, lung injury, endotoxic shock and others. This review will focus on the protective functions of HO-1.