Breastfeeding is associated with the production of type I interferon in infants infected with influenza virus.
Breastfeeding is associated with the production of type I interferon in infants infected with influenza virus.
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DOI：
10.1111/j.1651-2227.2010.01862.x
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Polack FP
中科院分区：
文献类型：
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作者：
Melendi GA;Coviello S;Bhat N;Zea-Hernandez J;Ferolla FM;Polack FP
母乳介导的对呼吸道病毒的保护作用已得到充分证实。然而，保护机制尚不清楚。I型干扰素（IFN）介导宿主防御呼吸道病毒，特别是流感病毒。I型干扰素、呼吸道病毒感染和母乳喂养之间的关系尚未探讨。用ELISA和真实的时间PCR研究了第一次呼吸道感染婴儿鼻分泌物中I型IFN的反应。在病毒感染期间，研究了母乳喂养对IFN的调节作用以及其他影响严重程度的变量。120名婴儿通过RT-PCR检测流感病毒（n = 24）、人偏肺病毒（hMPV）（n = 30）或呼吸道合胞病毒（RSV）（n = 66）呈阳性。I型IFN在感染流感病毒的婴儿中比感染RSV或hMPV的婴儿中更频繁地检测到。母乳喂养仅在感染流感病毒的婴儿中促进较高的I型IFN的比率和水平。年龄、性别或吸烟对IFN产生无影响。我们的研究证实，I型干扰素的生产更频繁地检测到感染流感病毒的婴儿。重要的是，这些婴儿中I型IFN的较高比率和水平与母乳喂养有关。这些观察结果表明，母乳可以通过激活宿主体内的先天抗病毒机制来预防呼吸道病毒。
Breast milk-mediated protection against respiratory viruses is well established. However, protective mechanisms are unclear. Type I interferons (IFN) mediate host defence against respiratory viruses, particularly influenza virus. The relationship among type I IFN, respiratory viral infections and breastfeeding has not been explored. Type I IFN responses were studied by ELISA and real time PCR in nasal secretions of infants experiencing their first respiratory infection. Modulation of IFN by breastfeeding and other variables affecting severity during viral infection was explored. One hundred and twenty infants were positive by RT-PCR for influenza virus (n = 24), human metapneumovirus (hMPV) (n = 30) or respiratory syncytial virus (RSV) (n = 66). Type I IFNs were detected more frequently in infants infected with influenza virus than in those infected with RSV or hMPV. Breastfeeding promoted higher rates and levels of type I IFN only in infants infected with influenza virus. No effect on IFN production was observed for age, gender or smoking. Our study confirms that type I IFN production is detected more frequently in infants infected with influenza virus. Importantly, higher rates and levels of type I IFN in these infants are associated with breastfeeding. These observations suggest that breast milk can protect against respiratory viruses by activating innate antiviral mechanisms in the host.