Preferential production and secretion of immunoglobulins by the equine endometrium--a mucosal immune system.
Preferential production and secretion of immunoglobulins by the equine endometrium--a mucosal immune system.
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马子宫内膜（粘膜免疫系统）优先产生和分泌免疫球蛋白。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
J. P. Hughes
中科院分区：
文献类型：
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作者：
G. Mitchell;I. Liu;L. Perryman;G. Stabenfeldt;J. P. Hughes
比较了10匹正常母马和7匹慢性子宫内膜病理母马血清和子宫盐水冲洗中免疫球蛋白的含量。分别在发情期和发情期采集样品。对于每种免疫球蛋白（IgA、IgG、IgG(T)、IgM），结果以子宫洗液或血清中存在的总免疫球蛋白的百分比表示。并比较了母马发情与雌情子宫标本免疫球蛋白浓度的变化，以及各组间子宫免疫球蛋白浓度的变化。正常母马发情期和发情期子宫总免疫球蛋白和IgG浓度变化显著，子宫IgA含量明显高于血清；两者在发情期均高于发情期。正常母马的IgA、IgG(T)、IgM在发情期与发情期之间无显著变化，亚育母马的总免疫球蛋白、IgA、IgG、IgG(T)、IgM在发情期与发情期之间无显著变化。亚育母马子宫液中总免疫球蛋白、IgA和IgG浓度明显高于正常母马。对子宫内膜活检标本进行马IgA、IgG、IgG(T)和IgM间接免疫荧光染色。正常母马的上皮IgA和亚育母马的上皮、腺分泌和浆细胞IgA均有检测。其他免疫球蛋白类别的特异性荧光未被注意到。
Immunoglobulin concentrations were compared in serum and in saline uterine washings from 10 normal mares and 7 subfertile mares with chronic endometrial pathology. Samples were collected in dioestrus and in oestrus. For each immunoglobulin class (IgA, IgG, IgG(T), IgM) the results were expressed as a percentage of total immunoglobulin present in uterine washings or serum. Comparison was also made between changes in immunoglobulin concentrations between dioestrous and oestrous uterine samples, and uterine immunoglobulin concentrations between groups of mares. There was significantly more IgA in the uterus than in serum and a significant change in uterine total immunoglobulin and IgG concentrations between dioestrus and oestrus in normal mares; both were higher in dioestrus than in oestrus. There were no significant changes in IgA, IgG(T), IgM in normal mares between dioestrus and oestrus, nor in total immunoglobulin, IgA, IgG, IgG(T) and IgM in subfertile mares. Subfertile mares had significantly higher total immunoglobulin, IgA and IgG concentrations in uterine fluid than did normal mares. Indirect immunofluorescent staining for equine IgA, IgG, IgG(T) and IgM was carried out on endometrial biopsy specimens. Epithelial IgA in normal mares and epithelial, glandular secretion and plasma cell IgA in subfertile mares were demonstrated. Specific fluorescence for other immunoglobulin classes was not noted.