Protocol for a randomised controlled trial investigating the effectiveness of an online e health application for the prevention of Generalised Anxiety Disorder.
Protocol for a randomised controlled trial investigating the effectiveness of an online e health application for the prevention of Generalised Anxiety Disorder.
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DOI：
10.1186/1471-244x-10-25
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发表时间：
2010-03-21
期刊：
影响因子：
4.4
通讯作者：
Bennett K
中科院分区：
文献类型：
--
作者：
Christensen H;Griffiths KM;Mackinnon AJ;Kalia K;Batterham PJ;Kenardy J;Eagleson C;Bennett K
广泛性焦虑症（GAD）是一种非常普遍的精神疾病。在青年期进行有效预防有可能减少这种疾病的流行，减少残疾，并降低这种疾病对社区造成的代价。目前的试验（WebGAD试验）旨在评估一个基于证据的在线预防网站对广泛性焦虑症的有效性。正在研究的主要临床问题是基于社区样本的在线广泛性焦虑症干预（E-couch）的有效性。我们研究了干预的效果是否可以通过电话形式的人工支持或通过电子邮件的自动支持来最大化。主要结果将是主动干预组相对于非主动干预组的GAD-7症状减轻。WebGAD试验将是第一个评估基于互联网的认知行为治疗（CBT）项目与预防GAD的可信对照条件的使用情况的试验，也是第一个使用社区招募的基于网络的GAD项目的正式随机对照试验评估。一般来说，基于网络的CBT项目在临床试验中已被证明对其他焦虑症如创伤后应激障碍、社交恐惧症、恐慌症和压力的治疗是有效的；然而，没有证据表明使用网络CBT可以预防广泛性焦虑症。鉴于澳大利亚和海外治疗师的严重短缺，以及精神疾病患者寻求治疗的低比率，该协议的成功实施具有重要的实际效果。如果发现有效，网络广泛性焦虑症将为那些经历广泛性焦虑症的人提供一个易于获得、免费的、基于证据的预防工具，可以立即进行推广和传播。Controlled-trials.com ISRCTN76298775
Generalised Anxiety Disorder (GAD) is a highly prevalent psychiatric disorder. Effective prevention in young adulthood has the potential to reduce the prevalence of the disorder, to reduce disability and lower the costs of the disorder to the community. The present trial (the WebGAD trial) aims to evaluate the effectiveness of an evidence-based online prevention website for GAD. The principal clinical question under investigation is the effectiveness of an online GAD intervention (E-couch) using a community-based sample. We examine whether the effect of the intervention can be maximised by either human support, in the form of telephone calls, or by automated support through emails. The primary outcome will be a reduction in symptoms on the GAD-7 in the active arms relative to the non active intervention arms. The WebGAD trial will be the first to evaluate the use of an internet-based cognitive behavioural therapy (CBT) program contrasted with a credible control condition for the prevention of GAD and the first formal RCT evaluation of a web-based program for GAD using community recruitment. In general, internet-based CBT programs have been shown to be effective for the treatment of other anxiety disorders such as Post Traumatic Stress Disorder, Social Phobia, Panic Disorder and stress in clinical trials; however there is no evidence for the use of internet CBT in the prevention of GAD. Given the severe shortage of therapists identified in Australia and overseas, and the low rates of treatment seeking in those with a mental illness, the successful implementation of this protocol has important practical outcomes. If found to be effective, WebGAD will provide those experiencing GAD with an easily accessible, free, evidence-based prevention tool which can be promoted and disseminated immediately. Controlled-trials.com: ISRCTN76298775