Dietary carotenoids and risk of colon cancer: Case‐control study
Dietary carotenoids and risk of colon cancer: Case‐control study
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膳食类胡萝卜素与结肠癌的风险：病例对照研究
DOI：
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发表时间：
2004
影响因子：
6.4
通讯作者：
P. Ghadirian
中科院分区：
文献类型：
--
作者：
A. Nkondjock;P. Ghadirian
一些流行病学研究表明，食用类胡萝卜素含量高的水果和蔬菜可以预防结肠癌（CC）。然而，证据并不完全一致。鉴于先前研究结果的不一致性以及对确定CC可改变的风险因素的持续兴趣，在加拿大蒙特利尔进行了一项法国加拿大人的病例对照研究，以检查饮食类胡萝卜素与CC风险之间的可能关联，并调查这种关联是否与生活方式因素（如吸烟或饮食）有关，特别是长链多不饱和脂肪酸（LCPUFA）的高消耗。共采访了402例结直肠病例（200例男性和202例女性）和688例年龄、性别和居住地匹配的基于人群的对照。饮食摄入量是通过一个有效的食物频率问卷，收集了200多个食物项目和食谱的信息进行评估。采用非条件Logistic回归模型计算比值比（OR）和95%置信区间（CI）。在调整了总能量摄入等重要变量后，未发现膳食类胡萝卜素摄入量与CC风险之间存在关联。对于摄入高LCPUFA的女性，发现叶黄素+玉米黄质与CC风险之间存在负相关。OR值为0.41;当摄入量的上四分位数与下四分位数比较时，二十碳五烯酸的OR=0.36，95%CI（0.19 -0.91），p =0.03，二十二碳六烯酸的OR=0.36，95%CI（0.19-0.78），p=0.01。在从不吸烟者中，CC风险显著降低与β-胡萝卜素摄入相关[OR=0.44，95%CI（0.21-0.92）和p=0.02]，而在吸烟者中，番茄红素摄入与CC风险之间存在负相关[OR=0.63，95%CI（0.40-0.98）和p=0.05]。我们的研究结果表明，富含叶黄素+玉米黄质和LCPUFA的饮食可能有助于预防法裔加拿大女性的CC。© 2004 Wiley利斯公司
Some epidemiological studies suggest that consumption of fruits and vegetables with a high carotenoid content may protect against colon cancer (CC). The evidence, however, is not completely consistent. Given the inconsistencies in findings in previous studies and continued interest in identifying modifiable risk factors for CC, a case‐control study of French‐Canadian in Montreal, Canada, was undertaken to examine the possible association between dietary carotenoids and CC risk and to investigate whether this association varies in relation to lifestyle factors such as smoking or diet, and particularly the high consumption of long‐chain polyunsaturated fatty acids (LCPUFA). A total of 402 colorectal cases (200 males and 202 females) and 688 population‐based controls matched for age, gender and place of residence were interviewed. Dietary intake was assessed through a validated food frequency questionnaire that collected information on over 200 food items and recipes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in unconditional logistic regression models. After adjustment for important variables such as total energy intake, no association was found between dietary intake of carotenoids and CC risk. For women with high intakes of LCPUFA, an inverse association was found between lutein + zeaxanthin and CC risk. ORs were 0.41; 95%CI (0.19–0.91), p=0.03 for eicosapentaenoic acid, and OR=0.36, 95%CI (0.19–0.78), p=0.01 for docosahexaenoic acid, when the upper quartiles of intake were compared to the lower. Among never‐smokers, a significantly reduced risk of CC was associated with intake of β‐carotene [OR=0.44, 95%CI (0.21–0.92) and p=0.02], whereas an inverse association was found between lycopene intake and CC risk [OR=0.63, 95%CI (0.40–0.98) and p=0.05] among smokers. The results of our study suggest that a diet rich in both lutein + zeaxanthin and LCPUFAs may help prevent CC in French‐Canadian females. © 2004 Wiley‐Liss, Inc.
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影响因子：
5
作者：
WILLETT, W;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
影响因子：
4.7
作者：
Li-Xin Zhang;R. Cooney;J. Bertram
通讯作者：
Li-Xin Zhang;R. Cooney;J. Bertram
影响因子：
20.1
作者：
Dubey, RK;Tyurina, YY;Kagan, VE
通讯作者：
Kagan, VE
DOI：
10.1093/ajcn/71.2.575
发表时间：
2000-02
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
M. Slattery;Joan Benson;K. Curtin;K. Ma;D. Schaeffer;J. Potter
通讯作者：
M. Slattery;Joan Benson;K. Curtin;K. Ma;D. Schaeffer;J. Potter
特定类胡萝卜素和维生素 A、C 和 E 的膳食摄入量以及结直肠腺瘤的患病率。
DOI：
--
发表时间：
1996
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Enger,SM;Longnecker,MP;Chen,MJ;Harper,JM;Lee,ER;Frankl,HD;Haile,RW
通讯作者：
Haile,RW