MicroRNA-mediated regulation of glucose and lipid metabolism.
MicroRNA-mediated regulation of glucose and lipid metabolism.
复制标题
DOI：
10.1038/s41580-021-00354-w
复制
发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Carthew RW
中科院分区：
文献类型：
--
作者：
Agbu P;Carthew RW
在动物中，代谢的系统控制由代谢组织进行，并依赖于过多分子（如激素和脂蛋白复合物）的调节循环。microRNA（miRNAs）是一个转录后基因抑制子家族，广泛存在于动物界，在各种环境中与基因表达调控密切相关，包括代谢系统调控的几乎所有方面。在这里，我们专注于葡萄糖和脂质代谢和审查目前的知识的作用，miRNA在其系统性调节。我们调查了miRNA介导的健康代谢调节以及miRNA对疾病代谢功能障碍的贡献，特别是糖尿病，肥胖和肝病。虽然大多数miRNA作用于它们产生的组织，但现在已经确定miRNA也可以在体液中循环，包括它们通过细胞外囊泡的细胞间转运，并且我们讨论了这种细胞外miRNA在全身代谢控制中的作用以及作为代谢状态和代谢疾病的潜在生物标志物。
In animals, systemic control of metabolism is conducted by metabolic tissues and relies on the regulated circulation of a plethora of molecules, such as hormones and lipoprotein complexes. MicroRNAs (miRNAs) are a family of post-transcriptional gene repressors that are present throughout the animal kingdom and have been widely associated with the regulation of gene expression in various contexts, including virtually all aspects of systemic control of metabolism. Here we focus on glucose and lipid metabolism and review current knowledge of the role of miRNAs in their systemic regulation. We survey miRNA-mediated regulation of healthy metabolism as well as the contribution of miRNAs to metabolic dysfunction in disease, particularly diabetes, obesity and liver disease. Although most miRNAs act on the tissue they are produced in, it is now well established that miRNAs can also circulate in bodily fluids, including their intercellular transport by extracellular vesicles, and we discuss the role of such extracellular miRNAs in systemic metabolic control and as potential biomarkers of metabolic status and metabolic disease.
登录
查看更多内容
影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
DOI：
10.1073/pnas.1808855115
发表时间：
2018-11-27
影响因子：
11.1
作者：
Castano, Carlos;Kalko, Susana;Parrizas, Marcelina
通讯作者：
Parrizas, Marcelina
DOI：
10.1161/atvbaha.119.313633
发表时间：
2020-02-01
影响因子：
8.7
作者：
Cheng, Joan;Cheng, Angela;Vallim, Thomas Q. de Aguiar
通讯作者：
Vallim, Thomas Q. de Aguiar
影响因子：
4.1
作者：
Chang, Jinhong;Nicolas, Emmanuelle;Taylor, John M
通讯作者：
Taylor, John M
DOI：
10.1073/pnas.2011243117
发表时间：
2020-09-22
影响因子：
11.1
作者：
Brandao, Bruna B.;Madsen, Soren;Mori, Marcelo A.
通讯作者：
Mori, Marcelo A.