A feedback-controlled ensemble model of the stuess-responsive hypothalamo-pituitary-adrenal axis
A feedback-controlled ensemble model of the stuess-responsive hypothalamo-pituitary-adrenal axis
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DOI：
10.1073/pnas.051624198
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发表时间：
2001-03-27
影响因子：
11.1
通讯作者：
Veldhuis, JD
中科院分区：
文献类型：
--
作者：
Keenan, DM;Licinio, J;Veldhuis, JD
The present work develops and implements a biomathematical statement of how reciprocal connectivity drives stress-adaptive homeostasis in the corticotropic (hypothalamo-pituitary-adrenal) axis. In initial analyses with this interactive construct, we test six specific a priori hypotheses of mechanisms linking circadian (24-h) rhythmicity to pulsatile secretory output. This formulation offers a dynamic framework for later statistical estimation of unobserved in vivo neurohormone secretion and within-axis, dose-responsive interfaces in health and disease. Explication of the core dynamics of the stress-responsive corticotropic axis based on secure physiological precepts should help to unveil new biomedical hypotheses of stressor-specific system failure.
