Ye-1, a monoclonal antibody that cross-reacts with HLA-B27 lymphoblastoid cell lines and an arthritis causing bacteria.
Ye-1, a monoclonal antibody that cross-reacts with HLA-B27 lymphoblastoid cell lines and an arthritis causing bacteria.
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Ye-1 是一种单克隆抗体，可与 HLA-B27 类淋巴母细胞系和引起关节炎的细菌发生交叉反应。
DOI：
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发表时间：
1985
影响因子：
4.6
通讯作者：
D. Yu
中科院分区：
文献类型：
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作者：
D. Kono;M. Ogasawara;R. Effros;M. Park;R. L. Waldord;D. Yu
用小肠结肠炎耶尔森氏菌（Yersinia enterocolitica，YE）免疫BALB/c小鼠，制备单克隆抗体Ye-1。该抗体与12个B27阳性的淋巴母细胞系均呈阳性反应，而与31个B27阴性的淋巴母细胞系仅呈4个阳性反应。4个反应性B27阴性细胞系中有3个为B7阳性。由于实验诱导的突变而失去B27表达的B27阳性细胞系变得与Ye-1不反应。这些结果支持了HLA-B27抗原与Y染色体之间存在交叉反应的可能性。小肠结肠炎
A monoclonal antibody, Ye-1, was generated by immunizing BALB/c mice with Yersinia enterocolitica. This antibody also reacted with all of 12 B27 positive lymphoblastoid cell lines, but only four of 31 B27 negative ones. Three of the four reactive B27 negative cell lines were B7 positive. A B27 positive cell line which has lost the B27 expression because of experimentally-induced mutation became unreactive with the Ye-1. These findings support the possibility that there is cross-reactivity between HLA-B27 antigens and Y. enterocolitica.