MOLECULAR MECHANISMS AND FORCES INVOLVED IN THE ADHESION AND FUSION OF AMPHIPHILIC BILAYERS
MOLECULAR MECHANISMS AND FORCES INVOLVED IN THE ADHESION AND FUSION OF AMPHIPHILIC BILAYERS
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DOI：
10.1126/science.2814514
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发表时间：
1989-11-17
期刊：
影响因子：
56.9
通讯作者：
MCGUIGGAN, PM
中科院分区：
文献类型：
--
作者：
HELM, CA;ISRAELACHVILI, JN;MCGUIGGAN, PM
采用表面力仪技术测量了水溶液中云母表面支撑的双层膜的粘附、变形和融合。导致双层膜直接融合的最重要的力是疏水相互作用，尽管融合的发生并不简单地与双层膜之间的力定律有关。双层在融合之前不需要“克服”一些排斥力障碍，例如水合作用。相反，一旦双层表面彼此在约1纳米的范围内，局部变形和分子重排使它们能够“绕过”这些力。
The surface forces apparatus technique was used for measuring the adhesion, deformation, and fusion of bilayers supported on mica surfaces in aqueous solutions. The most important force leading to the direct fusion of bilayers is the hydrophobic interaction, although the occurrence of fusion is not simply related to the force law between bilayers. Bilayers do not need to "overcome" some repulsive force barrier, such as hydration, before they can fuse. Instead, once bilayer surfaces come within about 1 nanometer of each other, local deformations and molecular rearrangements allow them to "bypass" these forces.