Role of N-glycans in growth factor signaling
Role of N-glycans in growth factor signaling
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DOI：
10.1023/b:glyc.0000024252.63695.5c
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发表时间：
2003-01-01
影响因子：
3
通讯作者：
Taniguchi, N
中科院分区：
文献类型：
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作者：
Takahashi, M;Tsuda, T;Taniguchi, N
分泌蛋白和膜蛋白经常被寡糖进行翻译后修饰。因此，许多糖蛋白参与信号转导。一个例子是生长因子受体，它是一种膜蛋白，通常含有寡糖。这些生长因子受体中的寡糖在受体功能中发挥着至关重要的作用。对糖基转移酶转染子的分析表明，寡糖的分支结构也是重要的决定因素。例如，表皮生长因子受体（EGFR）的N-聚糖参与受体分选、配体结合和二聚化。在 N-聚糖中添加平分 GlcNAc 会增加 EGFR 的内吞作用。 Trk（一种高亲和力神经生长因子受体）的 N-聚糖也会影响其功能。因此，寡糖在生长因子信号传导中发挥重要作用。 2004 年出版。
Secreted proteins and membrane proteins are frequently post-translationally modified by oligosaccharides. Therefore, many glycoproteins are involved in signal transduction. One example is growth factor receptors, which are membrane proteins that often contain oligosaccharides. The oligosaccharides in those growth factor receptors play crucial roles in receptor functions. An analysis of glycosyltransferase-transfectants revealed that the branching structures of oligosaccharide also serve as important determinants. For example, N-glycans of epidermal growth factor receptor (EGFR) are involved in receptor sorting, ligand binding and dimerization. The addition of a bisecting GlcNAc to N-glycans increases the endocytosis of EGFR. N-glycans of Trk, a high affinity nerve growth factor receptor, also affect its function. Thus, oligosaccharides play an important role in growth factor signaling. Published in 2004.