Distinct association of gene polymorphisms of estrogen receptor and vitamin D receptor with lumbar spondylosis in post-menopausal women
Distinct association of gene polymorphisms of estrogen receptor and vitamin D receptor with lumbar spondylosis in post-menopausal women
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DOI：
10.1007/s00586-005-0005-8
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发表时间：
2006-10
影响因子：
2.8
通讯作者：
Y. Koshizuka;N. Ogata;M. Shiraki;T. Hosoi;A. Seichi;K. Takeshita;Kozo Nakamura;H. Kawaguchi
中科院分区：
文献类型：
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作者：
Y. Koshizuka;N. Ogata;M. Shiraki;T. Hosoi;A. Seichi;K. Takeshita;Kozo Nakamura;H. Kawaguchi
流行病学研究表明，遗传背景对腰椎病病因的贡献。本研究旨在确定雌激素受体（ER）、维生素D受体（VDR）、甲状旁腺激素（PTH）和白细胞介素-1β (IL-1β)基因限制性内切片段长度多态性（RFLPs）与日本绝经后妇女腰椎间盘水平L1/2至L5/S1腰椎病放射学严重程度的关系。ER和VDR RFLP单倍型与颈椎病严重程度的相关性在较高水平（L1/2和L2/3）高于较低水平。ER基因型的相关性在年龄小于平均年龄的人群中更为明显，而VDR基因型的相关性在年龄较大的人群中更为显著。在任何分层组中，PTH和il - 1-β RFLP均与严重程度无关。因此，我们得出结论，ER和VDR基因可能以不同的方式导致腰椎病：雌激素敏感性影响绝经后早期的严重程度，而维生素D在老年时发挥重要作用，此时雌激素损失的贡献较弱。
Contribution of genetic backgrounds to the etiology of lumbar spondylosis has been suggested by epidemiological studies. This study was designed to determine the association of restriction fragment length polymorphisms (RFLPs) of estrogen receptor (ER), vitamin D receptor (VDR), parathyroid hormone (PTH) and interleukin-1β (IL-1β) genes with the radiological severity of lumbar spondylosis at the disk level from L1/2 to L5/S1 in Japanese post-menopausal women. ER and VDR RFLP haplotypes were associated with the severity of spondylosis in the upper levels (L1/2 and L2/3) more than in the lower levels. Association of ER genotype was more pronounced in the group younger than average than in the older group, while that of VDR genotype was more significant in the older group. Neither PTH nor IL1-β RFLP was associated with the severity at any levels in either stratified group. We thus conclude that ER and VDR genes may contribute to lumbar spondylosis in a distinct manner: estrogen sensitivity influences the severity in the early phase after menopause while vitamin D plays an important role at older ages when the contribution of estrogen loss is weaker.