Preferential Perinatal Development of Skin-Homing NK1.1+ Innate Lymphoid Cells for Regulation of Cutaneous Microbiota Colonization.
Preferential Perinatal Development of Skin-Homing NK1.1+ Innate Lymphoid Cells for Regulation of Cutaneous Microbiota Colonization.
复制标题
皮肤归巢 NK1.1 先天淋巴细胞的围产期优先发育，用于调节皮肤微生物群定植。
DOI：
10.1016/j.isci.2020.101014
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发表时间：
2020
期刊：
影响因子：
5.8
通讯作者：
Xiong,Na
中科院分区：
文献类型：
--
作者：
Yang,Jie;Restori,KatherineH;Xu,Ming;Song,EunHyeon;Zhao,Luming;Hu,Shaomin;Lyu,Pingyun;Wang,Wei-Bei;Xiong,Na
在早期个体发育阶段适当的免疫细胞发育对终身健康至关重要。如何在新生儿阶段在屏障组织中建立常驻免疫细胞以提供早期保护是一个重要但仍知之甚少的问题。我们在此报告，在围产期阶段，皮肤归巢组1先天淋巴样细胞（ILC1）的发育程序化优先生成有助于调节早期皮肤微生物群定植。我们发现，皮肤归巢NK1.1+ ILC1的人口优先产生于围产期小鼠胸腺。独特的胸腺环境和祖细胞负责在围产期优先产生皮肤归巢NK1.1+ ILC1。在皮肤中，NK1.1+ ILC1调节适当的微生物群定植并控制新生小鼠中的机会致病菌铜绿假单胞菌。这些发现提供了对新生儿阶段组织特异性免疫细胞的发育和功能的深入了解，这是建立局部组织免疫稳态的关键时间窗口。
Proper immune cell development at early ontogenic stages is critical for life-long health. How resident immune cells are established in barrier tissues at neonatal stages to provide early protection is an important but still poorly understood question. We herein report that a developmentally programmed preferential generation of skin-homing group 1 innate lymphoid cells (ILC1s) at perinatal stages helps regulate early skin microbiota colonization. We found that a population of skin-homing NK1.1+ILC1s was preferentially generated in the perinatal thymi of mice. Unique thymic environments and progenitor cells are responsible for the preferential generation of skin-homing NK1.1+ILC1s at perinatal stages. In the skin, NK1.1+ILC1s regulate proper microbiota colonization and control the opportunistic pathogenPseudomonas aeruginosain neonatal mice. These findings provide insight into the development and function of tissue-specific immune cells at neonatal stages, a critical temporal window for establishment of local tissue immune homeostasis.