[A New Method of Analyzing the Closing Volume (CV) Curve: "N2 First Derivative Wave Method"].
[A New Method of Analyzing the Closing Volume (CV) Curve: "N2 First Derivative Wave Method"].
复制标题
[一种分析收盘量（CV）曲线的新方法：“N2一阶导数波法”]。
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
S. Fujioka
中科院分区：
文献类型：
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作者：
S. Wada;T. Imai;K. Min;Kaoru Ogo;T. Miyamoto;Y. Okada;S. Fujioka
肺功能的评价涉及到许多因素的测量。闭合容积（CV）曲线是临床上重要的肺泡通气和气道闭合不均匀的指标。尽管用于CV测量的常规方法通常基于呼出氮（N2）浓度曲线相对于肺容量的模式，但是通常难以测量患有慢性阻塞性肺疾病（COPD）的患者的陡峭模式。在本文中，我们提出了一种新的方法，称为“N2一阶导数（fdN）波法”测量CV。将CV曲线的N2浓度转换为相对于肺体积的导数，这揭示了心源性振荡的存在。基于fdN波的斜率或振荡幅度的差异，III相和IV相之间的区分是直接的。我们的新方法能够区分阶段IV从阶段III使用的fdN波的振荡的振幅的差异，即使在COPD的CV曲线的陡峭模式的存在下。正常人包括COPD患者的肺泡平台斜率（ΔN2）与常规方法和新方法测得的CV值之间存在密切关系。总之，我们在本文中提出的新方法能够为包括COPD患者在内的所有受试者提供CV测量。[原文]
Evaluation of the lung function involves the measurement of many factors. The closing volume (CV) curve is clinically important as an index of uneven alveolar ventilation and airway closure. Although conventional methods for CV measurement are usually based on the pattern of the exhaled nitrogen (N2) concentration curve with respect to the lung volume, it is often difficult to measure the steep pattern of patients with chronic obstructive pulmonary disease (COPD). In this paper, we proposed a new method called the "N2 first derivative (fdN) wave method" for measuring CV. The N2 concentration of the CV curve was transformed to a derivative with respect to the lung volume, which revealed the existence of cardiogenic oscillations. Discrimination between phases III and IV was straightforward based on the difference in the slope or in the amplitude of oscillations of the fdN wave. Our new method was able to distinguish phase IV from phase III using the difference in amplitude of the oscillation of the fdN wave even in the presence of COPD with steep patterns of the CV curve. Close relationships were seen among normal subjects including COPD patients in both the slope of the alveolar plateau (ΔN2) and the CV values measured with the conventional and new methods. In conclusion, the new method we propose in this paper was able to provide measurements of CV for all subjects including those with COPD. [Original]