A review of recent progress in improving the bioavailability of nutraceutical‐loaded emulsions after oral intake
A review of recent progress in improving the bioavailability of nutraceutical‐loaded emulsions after oral intake
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DOI：
10.1111/1541-4337.13017
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Wei Liu
中科院分区：
文献类型：
--
作者：
Xing Chen;Yan Chen;Yikun Liu;Liqiang Zou;David Julian McClements;Wei Liu
Increasing awareness of the health benefits of specific constituents in fruits, vegetables, cereals, and other whole foods has sparked a broader interest in the potential health benefits of nutraceuticals. Many nutraceuticals are hydrophobic substances, which means they must be encapsulated in colloidal delivery systems. Oil-in-water emulsions are one of the most widely used delivery systems for improving the bioavailability and bioactivity of these nutraceuticals. The composition and structure of emulsions can be designed to improve the water dispersibility, physicochemical stability, and bioavailability of the encapsulated nutraceuticals. The nature of the emulsion used influences the interfacial area and properties of the nutraceutical-loaded oil droplets in the gastrointestinal tract, which influences their digestion, as well as the bioaccessibility, metabolism, and absorption of the nutraceuticals. In this article, we review recent in vitro and in vivo studies on the utilization of emulsions to improve the bioavailability of nutraceuticals. The findings from this review should facilitate the design of more efficacious nutraceutical-loaded emulsions with increased bioactivity.
