Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
复制标题
DOI：
10.1038/s41598-017-01208-2
复制
发表时间：
2017
影响因子：
4.6
通讯作者：
Yizhen Yu
中科院分区：
文献类型：
--
作者：
Hongjuan Chang;Qiuge Yan;Jie Tang;Juan Huang;Yanmei Zhang;Yuqiao Ma;Xiaozhou Ye;Lina Tang;Linguo Wu;Chunxia Wu;Yizhen Yu
Accumulating evidence suggests an association between the SIRT1 gene and human psychiatric.disorders. The aim of the study was to investigate the association between SIRT1 and predisposition.to antisocial personality traits (ASP) in Chinese adolescents. Participants consisted of 327 controls and.261 juvenile offenders who were diagnosed with predisposition to ASP according to the Personality.Diagnostic Questionnaire. Four tag single nucleotide polymorphisms (tagSNPs) of SIRT1, namely.rs12778366, rs7896005, rs10823112, and rs4746720, were genotyped. Association analysis between.individual SNPs and ASP risk revealed the CC genotype of rs4746720 to be significantly associated.with reduced risk of ASP (OR = 0.51, 95% CI = 0.33–0.77, adjusted P = 0.007). Haplotype analysis.showed the TAAC haplotype was associated with reduced susceptibility to ASP (OR = 0.72, 95%.CI = 0.57–0.91, P = 0.005). Moreover, rs4746720 variants were found to not only have a direct impact.on ASP susceptibility but also modulate the effect of alcohol consumption (Y = 0.022X + 0.431 vs..Y = −0.066X + 0.387). The present study is the first to report a significant association between SIRT1.polymorphisms and ASP in adolescents. This finding is expected to aid in the development of effective.interventions for this socially and personally costly disorder.
