Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization.
Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization.
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模块化生物信息学分析表明 Toll 样受体信号通路参与巨噬细胞极化的调节
DOI：
10.3892/mmr.2018.9486
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发表时间：
2018-11
影响因子：
3.4
通讯作者：
Xue D
中科院分区：
文献类型：
--
作者：
Ma B;Yang Y;Li Z;Zhao D;Zhang W;Jiang Y;Xue D
近年来，关于巨噬细胞在肿瘤、免疫应答和代谢中的作用的研究越来越多，其中巨噬细胞极化是一个广泛讨论的话题。在本研究中，差异表达的基因在各种类型的巨噬细胞进行了分析，使用基因表达综合数据库。对差异表达基因进行聚类分析，构建蛋白质相互作用（PPI）网络。最后，模块化分析和功能富集分析表明，Toll样受体（TLR）信号通路参与巨噬细胞极化的调节。此外，PPI网络中参与巨噬细胞极化的分子调节的高度蛋白质与TLR信号通路的蛋白质密切相关。这些结果表明TLR信号通路可能是未来巨噬细胞极化调控的主要研究方向。
In recent years, an increasing number of studies on the roles of macrophages in tumors, immune responses and metabolism have been published, in which macrophage polarization has been an extensively discussed topic. In the present study, differentially expressed genes in various types of macrophages were analyzed using the Gene Expression Omnibus database. Cluster analysis of differentially expressed genes was conducted, and a protein-protein interaction (PPI) network was constructed. Finally, modular analysis and functional enrichment analysis revealed that a Toll-like receptor (TLR) signaling pathway is involved in the regulation of macrophage polarization. Furthermore, the high-degree proteins in the PPI network that are involved in the molecular regulation of macrophage polarization are closely associated with proteins of the TLR signaling pathway. These results suggested that the TLR signaling pathways may be a principal direction of future research on the regulation of macrophage polarization.
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影响因子：
3.7
作者：
Marabita F;Almgren M;Lindholm ME;Ruhrmann S;Fagerström-Billai F;Jagodic M;Sundberg CJ;Ekström TJ;Teschendorff AE;Tegnér J;Gomez-Cabrero D
通讯作者：
Gomez-Cabrero D
通过其C末端结构域，细胞周期蛋白依赖性激酶抑制剂P21对于解决鼠炎性关节炎至关重要。
影响因子：
--
作者：
Mavers, Melissa;Cuda, Carla M.;Misharin, Alexander V.;Gierut, Angelica K.;Agrawal, Hemant;Weber, Evan;Novack, Deborah Veis;Haines, G. Kenneth, III;Balomenos, Dimitrios;Perlman, Harris
通讯作者：
Perlman, Harris
DOI：
10.1111/j.1582-4934.2008.00470.x
发表时间：
2009-08-01
影响因子：
5.3
作者：
Aly, Sahar;Mages, Joerg;Ehlers, Stefan
通讯作者：
Ehlers, Stefan
影响因子：
5.3
作者：
Grailer JJ;Haggadone MD;Sarma JV;Zetoune FS;Ward PA
通讯作者：
Ward PA
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA