PROPAGATION THROUGH ELECTRICALLY COUPLED CELLS - HOW A SMALL SA NODEDRIVES A LARGE ATRIUM
PROPAGATION THROUGH ELECTRICALLY COUPLED CELLS - HOW A SMALL SA NODEDRIVES A LARGE ATRIUM
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DOI：
10.1016/s0006-3495(86)83559-7
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发表时间：
1986-12-01
影响因子：
3.4
通讯作者：
VANCAPELLE, FJL
中科院分区：
文献类型：
--
作者：
JOYNER, RW;VANCAPELLE, FJL
每个正常的心动周期都是由一个动作电位启动的，该动作电位是由窦房结细胞的自律性启动的。然后，该动作电位从窦房结传播到周围的心房细胞。我们对电耦合细胞进行了数值模拟，以了解一个小的窦房结是如何自发激活的，同时又如何充分地与周围静止的心房细胞电耦合，从而在心房细胞中启动动作电位。我们用一个简单的两个耦合细胞模型和一个更复杂的二维单细胞模型的结果表明，窦房结内细胞在某种程度上的电去耦合可能是正常窦房结系统的一个基本设计特征。
Each normal cardiac cycle is started by an action potential that is initiated in the sino-atrial (SA) node by automaticity of the SA nodal cells. This action potential then propagates from the SA node into the surrounding atrial cells. We have done numerical simulations of electrically coupled cells to understand how a small SA node can be spontaneously active and yet be sufficiently electrically coupled to the surrounding quiescent atrial cells to initiate an action potential in the atrial cells. Our results with a simple model of two coupled cells and a more complex model of a two-dimensional sheet of cells suggest that some degree of electrical uncoupling of the cells within the SA node may be an essential design feature of the normal SA-atrial system.