COLLATERAL DEVELOPMENT AFTER CAROTID-ARTERY OCCLUSION IN FISCHER 344 RATS
COLLATERAL DEVELOPMENT AFTER CAROTID-ARTERY OCCLUSION IN FISCHER 344 RATS
复制标题
DOI：
10.1161/01.str.21.2.316
复制
发表时间：
1990-02-01
期刊：
影响因子：
8.3
通讯作者：
PANZENBECK, MJ
中科院分区：
文献类型：
--
作者：
COYLE, P;PANZENBECK, MJ
Fischer 344大鼠双侧颈总动脉永久性闭塞后的死亡率随着第一次和第二次闭塞之间的时间增加而降低。我们的目的是研究单侧颈动脉闭塞后侧支循环形成的可能性。在9只氯胺酮麻醉的雄性大鼠的双侧颈动脉暂时闭塞期间，平均值±。两侧顶叶皮质的SEM血流为23 ± 0.5%。4%的闭塞前（对照）血流量（120 ± 0.4%）。7 ml/min/100 g）（p < 0.05）。永久性闭塞一侧颈动脉1-3天（n = 10）或6周（n = 7）后，平均值±。SEM血流量为16 ± 0.5ml。2%和30 . ±. 3%的对照，分别在临时测试闭塞的另一个颈动脉。在测试闭塞期间，6周闭塞的同侧皮质中的血流量是对侧皮质中的血流量的170%（其类似于暂时闭塞两侧颈动脉后即刻的血流量），并且是闭塞1-2天后的两倍。6周闭塞同侧的基底动脉-颈动脉吻合口的平均管腔直径是对侧吻合口的186%，对侧吻合口仅显示出微小变化，闭塞1-2天后是对侧吻合口的145%。我们的结论是，在6周的永久性颈动脉闭塞的吻合口扩大，其血流量或储备增加。因此，侧支发展同侧，但不是对侧，6周的颈动脉闭塞，这表明更大的侧支保护的永久闭塞侧的可能性。
Mortality following permanent occlusion of both common carotid arteries decreases as the time between the first and second occlusions increases in Fischer 344 rats. Our goal was to examine the possibility that collaterals develop after unilateral carotid artery occlusion. During temporary occlusion of both carotid arteries in nine ketamine-anesthetized male rats, mean .+-. SEM blood flow in both parietal cortices was 23 .+-. 4% of the preocclusion (control) blood flow (120 .+-. 7 ml/min/100 g) measured by laser Doppler flowmetry (p < 0.05). After permanent occlusion of one carotid artery for either 1-3 days (n = 10) or 6 weeks (n = 7), mean .+-. SEM blood flow was 16 .+-. 2% and 30 .+-. 3% of control, respectively, during a temporary test occlusion of the other carotid artery. During the test occlusion, blood flow in the cortex ipsilateral to the 6-week occlusion was 170% that in the contralateral cortex (which was similar to the blood flow immediately after temporary occlusion of both carotid arteries) and twice that after 1-2 days of occlusion. Mean luminal diameter of the basilar-carotid anastomosis ipsilateral to the 6-week occlusion was 186% that of the contralateral anastomosis, which showed only minimal change, and 145% that after 1-2 days of occlusion. We conclude that during 6 weeks of permanent carotid artery occlusion the anastomosis enlarges and its blood flow or reserve increases. Thus, collaterals developed ipsilateral to, but not contralateral to, the 6-week carotid artery occlusion, which suggests the possibility of greater collateral protection on the permanently occluded side.