Hepatic Stellate Cell Regulation of Liver Regeneration and Repair.
Hepatic Stellate Cell Regulation of Liver Regeneration and Repair.
复制标题
肝星状细胞对肝脏再生和修复的调节作用。
DOI：
10.1002/hep4.1628
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发表时间：
2021-03
影响因子：
5.1
通讯作者：
Henderson NC
中科院分区：
文献类型：
--
作者：
Kitto LJ;Henderson NC
肝间质已在肝纤维化的背景下被广泛研究；然而，关于间充质细胞在肝脏再生中的作用，我们所知甚少。单细胞基因组学方法最近揭示了肝内稳态和肝损伤后肝间质的空间和功能分区。在这里，我们讨论了临床前模型的使用如何帮助我们理解肝再生过程中间质的作用，以及这些方法如何促进对肝脏疾病患者的高靶向、促再生治疗的精确识别。肝间质已在肝纤维化的背景下被广泛研究；然而，关于间充质细胞在肝脏再生中的作用，我们所知甚少。随着我们对推动肝再生的细胞和分子机制的了解不断加深，间充质室在再生反应中的关键作用越来越受到重视。单细胞基因组学方法最近揭示了肝内稳态和肝损伤后肝间质的空间和功能分区。在这里，我们讨论了如何使用临床前模型，从体内小鼠模型到基于类器官的系统，帮助我们理解肝再生过程中间质的作用，以及这些方法如何促进对肝脏疾病患者的高度靶向、促再生治疗的精确识别。
The hepatic mesenchyme has been studied extensively in the context of liver fibrosis; however, much less is known regarding the role of mesenchymal cells during liver regeneration. Single‐cell genomics approaches have recently uncovered both spatial and functional zonation of the hepatic mesenchyme in homeostasis and following liver injury. Here we discuss how the use of preclinical models are helping to shape our understanding of the role of the mesenchyme during liver regeneration, and how these approaches should facilitate the precise identification of highly targeted, pro‐regenerative therapies for patients with liver disease. The hepatic mesenchyme has been studied extensively in the context of liver fibrosis; however, much less is known regarding the role of mesenchymal cells during liver regeneration. As our knowledge of the cellular and molecular mechanisms driving hepatic regeneration deepens, the key role of the mesenchymal compartment during the regenerative response has been increasingly appreciated. Single‐cell genomics approaches have recently uncovered both spatial and functional zonation of the hepatic mesenchyme in homeostasis and following liver injury. Here we discuss how the use of preclinical models, from in vivo mouse models to organoid‐based systems, are helping to shape our understanding of the role of the mesenchyme during liver regeneration, and how these approaches should facilitate the precise identification of highly targeted, pro‐regenerative therapies for patients with liver disease.
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影响因子：
25.7
作者：
Fausto, N
通讯作者：
Fausto, N
影响因子：
29.4
作者：
Enami, Yuta;Bandi, Sriram;Gupta, Sanjeev
通讯作者：
Gupta, Sanjeev
DOI：
10.1002/hep.30109
发表时间：
2019-04
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Bhushan B;Stoops JW;Mars WM;Orr A;Bowen WC;Paranjpe S;Michalopoulos GK
通讯作者：
Michalopoulos GK
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
2.2
作者：
Duncan AW;Soto-Gutierrez A
通讯作者：
Soto-Gutierrez A