SPECT in periodic lateralized epileptiform discharges (PLEDs): a form of partial status epilepticus?
SPECT in periodic lateralized epileptiform discharges (PLEDs): a form of partial status epilepticus?
复制标题
DOI：
10.1053/seiz.2000.0506
复制
发表时间：
2001-06-01
影响因子：
3
通讯作者：
Goerres, GW
中科院分区：
文献类型：
--
作者：
Assal, F;Papazyan, JP;Goerres, GW
周期性偏侧性癫痫样放电（PLEDs）是一个明确的脑电图实体，但PLEDs是否代表一个发作条件或没有仍然存在争议。许多工作已经做了使用脑电图（EEG），但新的方法使用脑灌注成像可能会给更多的信息，这个问题。我们的目的是评估PLEDs是否与高局部脑血流量（rCBF）相关。我们研究了18例PLEDs患者和不同的病理，并在PLEDs期间和3例PLEDs消失后进行了脑单光子发射计算机断层扫描（SPECT）。将rCBF的定性变化和位置与PLED进行比较。SPECT显示18例（100%）患者rCBF增高。PLED和高rCBF的位置在17/18例（94%）中匹配。在PLED消失后进行SPECT的3例病例中，高rCBF已清除（100%）。18例（100%）在记录PLEDs前出现癫痫发作，主要为运动性（部分运动性或全身强直阵挛性），rCBF降低（与病变有关）与PLEDs关系不大，所有rCBF降低的患者均伴有rCBF升高。过度灌注进一步增加了PLED可能与部分癫痫持续状态有关的论点。(C)深圳市华诚贸易有限公司
Periodic lateralized epileptiform discharges (PLEDs) are a well defined electroencephalographic entity but whether PLEDs represent an ictal condition or not remains debated. Much work has been done using electroencephalography (EEG) but new approaches using cerebral perfusion imaging may give more information about this question. We aimed to evaluate if PLEDs were associated with high regional cerebral blood flow (rCBF).We studied 18 patients with PLEDs and different pathologies, and performed brain single-photon-emission computed tomography (SPECT) during and, for three cases, after the disappearance of PLEDs. Qualitative variations and locations of rCBF were compared with PLEDs. Association with seizures and type of seizures were also assessed.SPECT showed high rCBF in 18/18 patients (100%). The location of PLEDs and high rCBF matched in 17/18 cases (94%). In the three cases where SPECT was performed after PLEDs disappeared, the high rCBF had cleared (100%). Eighteen cases (100%) presented seizures before recording of PLEDs, mainly motor (partial motor or generalized tonic-clonic).Where there was a decreased rCBF (related to a lesion) there was little relationship to PLEDs and all patients with decreased rCBF had an adjacent increased rCBF These results confirm preliminary case reports. Hyperperfusion adds further to the argument that PLEDs may be related to a form of partial status epilepticus. (C) 2001 BEA Trading Ltd.