Evolution and differentiation of MSHR gene in different species.
Evolution and differentiation of MSHR gene in different species.
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DOI：
10.1093/jhered/esl059
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发表时间：
2007-03
期刊：
影响因子：
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通讯作者：
Xianglong Li;Guiru Zheng;R. Zhou;Lan-hui Li
中科院分区：
文献类型：
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作者：
Xianglong Li;Guiru Zheng;R. Zhou;Lan-hui Li
毛色为进化研究提供了一些前景，因为它具有大量可能的适应性毛色变异以及在不同物种中产生不同毛色的保守遗传机制。黑素细胞刺激激素受体（MSHR）基因负责哺乳动物和鸟类的种内和种间颜色变化。对20科84种、58属、206个MSHR基因序列进行分析，探讨其在不同物种中的进化和分化。大多数物种有 954 bp 和终止密码子 TGA。 Callithrix 和 Callimico 的物种具有从 TGA 到 TGG 的终止密码子突变，并以 TAG 作为终止密码子延长 81 bp。雉科、燕雀科和狐猴科的物种也使用 TAG 作为终止密码子。野猪插入了编码 Asn-Gln-Thr 的 AACCAGACC，长度为 85 至 93 bp。在牛科动物中，由于编码 Gly-Ile-Ala-Arg 的 GGCATTGCCCGG 从 670 bp 到 681 bp 的 12 bp 重复，发现了 966 bp 的棕色牛品系。 Teiidae的总突变数（6个）、沉默突变（3个）、非同义突变（3个）、平均核苷酸差异数（1.519）、同义核苷酸多样性（pi(s) = 0.0030）和非同义核苷酸多样性（pi(a) = 0.0029）最少，而人科、狐猴科、犬科和Teiidae的比例较高。 pi(a)/pi(s) (0.537-0.973)。重建的家系MSHR基因系统发育树与国家生物技术信息中心的分类基本一致。
Coat color offers some prospects for evolutionary studies due to its large amount of presumably adaptive coat color variation and conserved genetic mechanisms of generating different coat colors in different species. Melanocyte-stimulating hormone receptor (MSHR) gene is responsible for intraspecific and interspecific color variation in mammals and birds. A total number of 206 MSHR gene sequences belonging to 84 species, 58 genera, and 20 families were analyzed to investigate its evolution and differentiation in different species. Most of the species have 954 bp and stop codon TGA. Species in Callithrix and Callimico have a stop codon mutation from TGA to TGG and elongate 81 bp with TAG as stop codon. Species in Phasianidae, Fringillidae, and Lemuridae also use TAG as stop codon. The Sus scrofa had an insertion of AACCAGACC encoding Asn-Gln-Thr from 85 to 93 bp. In Bovidae, a brown strain of cow with 966 bp due to the 12-bp duplication of GGCATTGCCCGG from 670 to 681 bp encoding for Gly-Ile-Ala-Arg was found. Teiidae has the smallest number of total mutations (6), silent mutations (3), nonsynonymous mutations (3), average number of nucleotide differences (1.519), synonymous nucleotide diversity (pi(s) = 0.0030), and nonsynonymous nucleotide diversity (pi(a) = 0.0029), and Hominidae, Lemuridae, Canidae, and Teiidae have higher ratio of pi(a)/pi(s) (0.537-0.973). The reconstructed phylogenetic tree of MSHR gene of families is basically consistent with the taxonomy of National Center for Biotechnology Information.