Synergistic antitumor effect of adenovirus-mediated hING4 gene therapy and 125I radiation therapy on pancreatic cancer
Synergistic antitumor effect of adenovirus-mediated hING4 gene therapy and 125I radiation therapy on pancreatic cancer
复制标题
腺病毒介导的 hING4 基因治疗和 (125)I 放射治疗对胰腺癌的协同抗肿瘤作用。
DOI：
10.1016/j.canlet.2011.11.003
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发表时间：
2012-03-28
期刊：
影响因子：
9.7
通讯作者：
Yang Jicheng
中科院分区：
文献类型：
--
作者：
Zhao Yaodong;Su Chenghai;Yang Jicheng
胰腺癌的预后很差，即使进行手术。ING 4是生长抑制因子（inhibitor of growth，ING）家族中的一员，对多种肿瘤具有较强的抑制作用，同时放射治疗也是胰腺癌常用的治疗手段。在这项研究之前，ING 4基因治疗和放射治疗联合治疗胰腺癌的有效性尚不清楚。在这项研究中，我们证明了ING 4或I-125放射治疗可以诱导Panc-1胰腺癌细胞生长抑制和凋亡。此外，两种治疗均抑制体内皮下异种移植的Panc-1胰腺癌的肿瘤生长和血管生成。此外，联合治疗具有协同效应。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Pancreatic cancer has a poor prognosis, even with surgery. ING4 is a member of the inhibitor of growth (ING) tumor suppressor family that has potent inhibitory effects on a variety of tumors; meanwhile, radiotherapy is a common adjunctive therapy for pancreatic cancer. Prior to this study, the effectiveness of a combination of ING4 gene-therapy and radiotherapy against pancreatic cancer had been unknown. In this study, we demonstrated that either ING4 or I-125 radiotherapy treatment could induce Panc-1 pancreatic cancer cell growth suppression and apoptosis in vitro. Furthermore, both treatments inhibited tumor growth and angiogenesis of Panc-1 pancreatic cancer subcutaneously xenografted in vivo. Moreover, the combination therapy had a synergistic effect. (C) 2011 Elsevier Ireland Ltd. All rights reserved.