The effect of some factors on the faecal concentration of acid steroids, neutral steroids and urobilins
The effect of some factors on the faecal concentration of acid steroids, neutral steroids and urobilins
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一些因素对酸性类固醇、中性类固醇和尿胆素粪便浓度的影响
DOI：
10.1002/path.1711040405
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
M. J. Hill
中科院分区：
文献类型：
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作者：
M. J. Hill
在之前的论文(Hill和Aries，1971)中，据报道，英格兰人和苏格兰人的粪便中酸性类固醇、中性类固醇和尿胆素的浓度比乌干达人和印度人的要高得多。就乌干达人而言，尿胆素和中性类固醇的低浓度可能仅仅是由于稀释，因为乌干达人每天产生的粪便重量比英格兰人或苏格兰人大得多，但这种差异不足以解释酸性类固醇的低浓度。印度人每天的排泄量只是欧洲人的两倍，所以稀释不能解释他们类固醇产量低的原因。对粪便中酸性类固醇浓度差异的可能解释包括(A)饮食、(B)种族和(C)环境。本文报道了年龄、性别和膳食脂肪对粪便中胆汁酸、中性类固醇和尿胆蛋白浓度的影响。本文还报道了粪便胆汁酸浓度与胆汁酸脱羟化度的关系。
IN the previous paper (Hill and Aries, 1971) it was reported that the concentration of acid steroids, neutral steroids and urobilins was much greater in faeces from English and Scottish people than from Ugandans and Indians. In the case of the Ugandans the low concentration of urobilins and neutral steroids might merely be due to dilution, since Ugandans produce a much greater weight of faeces per day than do the English or Scots, but this difference is insufficient to explain the low concentration of acid steroids. Indians produce only twice the daily faecal mass of Europeans, so dilution could not explain their low steroid output. Possible explanations of the differences in faecal acid-steroid concentration include (a) diet, (b) race and (c) environment. In this paper we report an investigation into the effect of age, sex and dietary fat on the faecal concentration of bile acids, neutral steroids and urobilins. The relation between faecal bile-acid concentration and the degree of bile-acid dehydroxylation is also reported.