POOR PLASMA STATUS OF CAROTENE AND VITAMIN-C IS ASSOCIATED WITH HIGHER MORTALITY FROM ISCHEMIC-HEART-DISEASE AND STROKE

DOI：

10.1007/bf00210955

发表时间：

1993-01-01

期刊：

CLINICAL INVESTIGATOR

影响因子：

通讯作者：

中科院分区：

其他

文献类型：

作者：

GEY, KF;STAHELIN, HB;EICHHOLZER, M

先前缺血性心脏病死亡率的跨文化比较。血浆中必需抗氧化剂水平与维生素E呈很强的负相关，与其他抗氧化剂的相关性相对较弱。同样，在爱丁堡的一项病例对照研究中，低血浆维生素E水平与先前未确诊的心绞痛风险增加显著相关，而低水平的其他必需抗氧化剂缺乏统计学意义。目前的巴塞尔前瞻性研究特别适合阐明除维生素E以外的抗氧化剂的影响。在这一人群中（最近对癌症死亡率进行了评估），血浆中维生素E和A的水平异常高，高于缺血性心脏病风险的假定阈值水平。本研究对心血管疾病死亡率进行了为期12年的随访，发现血浆中胡萝卜素水平较低时，缺血性心脏病和中风的相对风险显著增加(

Previous cross-cultural comparisons of the mortality from ischemic heart disease. in European communities with associated plasma levels of essential antioxidants have revealed strong inverse correlations for vitamin E and relatively weak correlations for other antioxidants. Similarly, in a case-control study in Edinburgh low plasma levels of vitamin E were significantly associated with an increased risk of previously undiagnosed angina pectoris whereas low levels of other essential antioxidants lacked statistical significance. The current Basel Prospective Study is particularly well suited to elucidate the impact of antioxidants other than vitamin E. In this population (which was recently evaluated regarding cancer mortality) the plasma levels of vitamins E and A are exceptionally high and above the presumed threshold level of risk for ischemic heart disease. The present 12-year follow-up of cardiovascular mortality in this study reveals a significantly increased relative risk of ischemic heart disease and stroke at initially low plasma levels of carotene (

POOR PLASMA STATUS OF CAROTENE AND VITAMIN-C IS ASSOCIATED WITH HIGHER MORTALITY FROM ISCHEMIC-HEART-DISEASE AND STROKE - BASEL PROSPECTIVE-STUDY

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