Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings.
Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings.
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DOI：
10.1016/j.appet.2015.08.009
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发表时间：
2016-01-01
期刊：
影响因子：
5.4
通讯作者：
Carnell S
中科院分区：
文献类型：
--
作者：
Geliebter A;Benson L;Pantazatos SP;Hirsch J;Carnell S
肥胖者对高热量食物的神经反应会发生改变。暴饮暴食的个体表现出高度的冲动性和情绪化，可能表现出相关但独特的不规则神经反应模式。然而，很少有神经影像学研究比较BE和非BE组。为了研究BE中对食物线索的神经反应，10名BE女性和10名无BE女性（非BE），她们与肥胖相匹配（每组5名肥胖和5名消瘦），在呈现代表高能量密度（艾德）食物、低艾德食物和非食物的视觉（图片）和听觉（口语）线索时进行了fMRI扫描。然后，我们比较了BE组和非BE组中高ED和低ED食物的局部大脑激活。为了探索功能连接的差异，我们还比较了BE组与非BE组的心理生理相互作用[PPI]与背侧前扣带皮层[dACC]。感兴趣区域（ROI）分析显示，BE组在dACC中显示出比非BE组更多的激活，在纹状体或OFC中没有激活差异。探索性PPI分析显示，BE组与非BE组相比，在小脑、小脑和边缘上回中与dACC的功能连接更强。我们的研究结果表明，BE女性在dACC中表现出高反应性，并且当呈现高ED提示时，与其他大脑区域的耦合增加。这些差异与体重无关，似乎与BE表型相关。
Obese individuals show altered neural responses to high-calorie food cues. Individuals with binge eating [BE], who exhibit heightened impulsivity and emotionality, may show a related but distinct pattern of irregular neural responses. However, few neuroimaging studies have compared BE and non-BE groups. To examine neural responses to food cues in BE, 10 women with BE and 10 women without BE (non-BE) who were matched for obesity (5 obese and 5 lean in each group) underwent fMRI scanning during presentation of visual (picture) and auditory (spoken word) cues representing high energy density (ED) foods, low-ED foods, and non-foods. We then compared regional brain activation in BE vs. non-BE groups for high-ED vs. low-ED foods. To explore differences in functional connectivity, we also compared psychophysiologic interactions [PPI] with dorsal anterior cingulate cortex [dACC] for BE vs. non-BE groups. Region of interest (ROI) analyses revealed that the BE group showed more activation than the non-BE group in the dACC, with no activation differences in the striatum or OFC. Exploratory PPI analyses revealed a trend towards greater functional connectivity with dACC in the insula, cerebellum, and supramarginal gyrus in the BE vs. non-BE group. Our results suggest that women with BE show hyper-responsivity in the dACC as well as increased coupling with other brain regions when presented with high-ED cues. These differences are independent of body weight, and appear to be associated with the BE phenotype.