A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium.
A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium.
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DOI：
10.1016/j.dadm.2015.10.004
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Ikram MA
中科院分区：
文献类型：
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作者：
Adams HH;Hilal S;Schwingenschuh P;Wittfeld K;van der Lee SJ;DeCarli C;Vernooij MW;Katschnig-Winter P;Habes M;Chen C;Seshadri S;van Duijn CM;Ikram MK;Grabe HJ;Schmidt R;Ikram MA
Virchow-Robin间隙（VRS）或血管周围间隙是包围脑血管的间质液的隔室，是各种潜在脑病变的潜在成像标记物。尽管对扩大的VRS的研究越来越感兴趣，但评级和量化方法的异质性与小样本量相结合，迄今为止阻碍了该领域的发展。Virchow-Robin Spaces Ensemination统一神经成像（UNIVRSE）联盟成立的主要目的是协调评级和分析（www.uconsortium.org）。UNIVRSE联盟汇集了来自五个国家的13个（子）队列，总计16，000名受试者和超过25，000次扫描。八个不同的磁共振成像协议中使用的财团。使用由两位创始成员开发的经验证的方案协调VRS评级，具有独立于扫描仪类型、评级者经验或伴随脑病理学的高可靠性。初步分析显示，VRS扩大的危险因素包括年龄增加、性别、高血压、脑梗死和白色病变，但这因脑区而异。队列研究之间在数据协调和联合分析方面的早期合作努力可以推进人群（神经）成像领域。UNIVRSE联盟将集中精力研究扩大VRS的其他潜在相关因素，包括遗传学，认知，中风和痴呆。
Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field. The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium. VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region. Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.