Fibroblast responses to variation in soft tissue mobilization pressure
Fibroblast responses to variation in soft tissue mobilization pressure
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DOI：
10.1097/00005768-199904000-00006
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发表时间：
1999-04-01
期刊：
影响因子：
--
通讯作者：
Helfst, R
中科院分区：
文献类型：
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作者：
Gehlsen, GM;Ganion, LR;Helfst, R
增强软组织动员疗法（ASTM）是一种新兴的按摩疗法，已成功地用于治疗慢性肌腱炎患者。我们的理论是，ASTM技术通过控制微创伤的应用促进愈合。目的：本研究的目的是确定形态学变化后，在大鼠跟腱酶诱导的损伤与胶原酶和随后的压力变化，在ASTM治疗。研究方法：将30只雄性白色大鼠随机分配到5组中的一组，每组6只动物：肌腱炎（A）、肌腱炎+轻度ASTM（B）、肌腱炎+中度ASTM（C）、肌腱炎+极端ASTM（D）和仅手术的对照组（E）。ASTM进行3分钟，共进行6次治疗。在最后一次ASTM治疗后1wk，取跟腱。通过光学显微镜评估成纤维细胞数量。电镜下观察成纤维细胞增大。结果：D组成纤维细胞数与其他各组比较有显著性差异（P < 0.00）。结论：形态学证据表明，施加重压比轻或中等压力更大程度地促进愈合过程。
Augmented soft tissue mobilization therapy (ASTM), a newly developed massage therapy, has been successfully used in the treatment of chronic tendinitis patients. We theorized that the ASTM technique promotes healing through a controlled application of microtrauma. Purpose: The purpose of this study was to determine morphologic changes in the rat Achilles tendon after enzyme-induced injury with collagenase and subsequent pressure variations in ASTM therapy. Methods: Thirty male white rats were randomly assigned to one of five groups with six animals per group: tendinitis (A), tendinitis plus light ASTM (B), tendinitis plus medium ASTM (C), tendinitis plus extreme ASTM (D), and control with surgery only (E). ASTM was performed for 3 min, for a total of six treatment sessions. The Achilles tendons of each group were harvested 1 wk after the last ASTM treatment. Fibroblast numbers were assessed by light microscopy. An electron microscope was used to observe enlargement of fibroblasts. Results: Statistical analysis of the number of flbroblasts present indicated a significant difference (P < 0.00) between group D and all other groups. Conclusion: The morphological evidence indicated that the application of heavy pressure promoted the healing process to a greater degree than light or moderate pressure.