Persistently active neurons in human medial frontal and medial temporal lobe support working memory.
Persistently active neurons in human medial frontal and medial temporal lobe support working memory.
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DOI：
10.1038/nn.4509
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发表时间：
2017-04
影响因子：
25
通讯作者：
Rutishauser U
中科院分区：
文献类型：
--
作者：
Kamiński J;Sullivan S;Chung JM;Ross IB;Mamelak AN;Rutishauser U
持续的神经活动是维持工作记忆的一种假定机制。持续的活动依赖于一个分布式区域网络的活动，但每个区域的不同贡献仍不清楚。我们记录了人类内侧额叶皮层和内侧颞叶中的单个神经元，而受试者在记忆中持有多达三个项目。我们在两个区域都发现了持续活跃的神经元。海马和杏仁核神经元的持续活动是刺激特异性的，形成稳定的吸引子，并预测记忆内容。内侧额叶皮层持续活动，另一方面，调制的记忆负荷和任务设置，但不是刺激特异性。在这两个区域的持续活动中，每次试验的变化都与记忆强度有关，因为它预测了刺激被记住的速度和准确性。这项工作揭示了，在人类中，持续活跃的神经元支持工作记忆维持的分布式网络的直接证据。
Persistent neural activity is a putative mechanism for the maintenance of working memories. Persistent activity relies on the activity of a distributed network of areas, but the differential contribution of each area remains unclear. We recorded single neurons in the human medial frontal cortex and the medial temporal lobe while subjects held up to three items in memory. We found persistently active neurons in both areas. Persistent activity of hippocampal and amygdala neurons was stimulus-specific, formed stable attractors, and was predictive of memory content. Medial frontal cortex persistent activity, on the other hand, was modulated by memory load and task set but was not stimulus-specific. Trial-by-trial variability in persistent activity in both areas was related to memory strength, because it predicted the speed and accuracy by which stimuli were remembered. This work reveals, in humans, direct evidence for a distributed network of persistently active neurons supporting working memory maintenance.