mRNA imprinting: Additional level in the regulation of gene expression.
mRNA imprinting: Additional level in the regulation of gene expression.
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DOI：
10.4161/cl.1.1.14465
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Choder, Mordechai
中科院分区：
文献类型：
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作者：
Choder, Mordechai
在细胞核中合成之后，mRNA经历了不同的阶段，这些阶段对其编码蛋白的正确合成、定位和可能的功能至关重要。最近，我们发现两个RNA聚合酶II （Pol II）亚基Rpb4p和Rpb7p与新生转录物共转录相关。这种“mRNA印记”贯穿mRNA的整个生命周期，是mRNA经历的所有主要阶段的适当调节所必需的。讨论了其他可能的共转录印迹的情况。由于mRNA可以从合成细胞转运到其他细胞，我们提出mRNA印迹也可以影响受体细胞的表型。这可以被看作是“基于mrna的表观遗传学”。
Following its synthesis in the nucleus, mRNA undergoes various stages that are critical for the proper synthesis, localization and possibly functionality of its encoded protein. Recently, we have shown that two RNA polymerase II (Pol II) subunits, Rpb4p and Rpb7p, associate with the nascent transcript co-transcriptionally. This "mRNA imprinting" lasts throughout the mRNA lifetime and is required for proper regulation of all major stages that the mRNA undergoes. Other possible cases of co-transcriptional imprinting are discussed. Since mRNAs can be transported from the synthesizing cell to other cells, we propose that mRNA imprinting can also affect the phenotype of the recipient cells. This can be viewed as "mRNA-based epigenetics."